CAS 508-44-1|Anemonine

Introduction：Basic information about CAS 508-44-1|Anemonine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Anemonine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Anemonine
CAS Number	508-44-1	Molecular Weight	192.17
Density	1.45	Boiling Point	535.7ºC at 760 mmHg
Molecular Formula	C₁₀H₈O₄	Melting Point	157-158ºC
MSDS	/	Flash Point	300.7ºC

Names

Name	1,7-Dioxadispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione
Synonym	More Synonyms

Anemonine BiologicalActivity

Description	Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].
Related Catalog	Signaling Pathways >>Epigenetics >>PKCSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>TGF-beta/Smad >>PKC
References	[1]. Jiang L, et al. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39. [2]. Lee TH, et al. Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. J Ethnopharmacol. 2008 Mar 28;116(3):518-27.

Description

Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases[1][2].

Related Catalog

Signaling Pathways >>Epigenetics >>PKCSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>TGF-beta/Smad >>PKC

References

[1]. Jiang L, et al. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39.

[2]. Lee TH, et al. Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. J Ethnopharmacol. 2008 Mar 28;116(3):518-27.

Chemical & Physical Properties

Density	1.45
Boiling Point	535.7ºC at 760 mmHg
Melting Point	157-158ºC
Molecular Formula	C₁₀H₈O₄
Molecular Weight	192.17
Flash Point	300.7ºC
Exact Mass	192.04200
PSA	52.60000
LogP	0.48380
Index of Refraction	1.61
InChIKey	JLUQTCXCAFSSLD-NXEZZACHSA-N
SMILES	O=C1C=CC2(CCC23C=CC(=O)O3)O1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JG7875000

CHEMICAL NAME :: 1,7-Dioxadispiro(4.0.4.2)dodeca-3,9-diene-2,8-dione, trans-

CAS REGISTRY NUMBER :: 508-44-1

BEILSTEIN REFERENCE NO. :: 0009390

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H8-O4

MOLECULAR WEIGHT :: 192.18

WISWESSER LINE NOTATION :: T5VOXJ C-& AL4XXTJ B-& CT5VOXJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946

Synonyms

1,7-Dinitro-naphthalin

1,7-dinitro-naphthalene

1,7-dioxa-dispiro[4.0.4.2]dodeca-3,9-diene-2,8-dione

Naphthalene,1,7-dinitro

1,7-Dioxa-dispiro[4.0.4.2]dodeca-3,9-dien-2,8-dion

Anemonine

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