CAS 22494-47-9|Clozic

Introduction：Basic information about CAS 22494-47-9|Clozic, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameClozic
CAS Number22494-47-9Molecular Weight304.76800
Density1.218g/cm3Boiling Point472ºC at 760mmHg
Molecular FormulaC17H17ClO3Melting Point/
MSDS/Flash Point239.2ºC

Names

Name2-[[4-(4-chlorophenyl)phenyl]methoxy]-2-methylpropanoic acid
SynonymMore Synonyms

Clozic BiologicalActivity

DescriptionClozic is a potential anti-arthritic agent.
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In VitroClozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media[1].
Cell AssayApproximately 3×104 to 5×104 cells/mL medium are seeded into 24-well plates and incubated at 37°C in a humidified atmosphere of 95% air/5% CO2. Medium is replaced with fresh medium containing 20% foetal calf serum and methanol or Clozic under investigation. Cell numbers are determined in replicate wells on various days during culture growth[1].
References

[1]. Foster SJ, et al. Anti-proliferative properties of Clozic, a disease-modifying anti-arthritic agent. Biochem Pharmacol. 1983 Feb 1;32(3):461-7.

Chemical & Physical Properties

Density1.218g/cm3
Boiling Point472ºC at 760mmHg
Molecular FormulaC17H17ClO3
Molecular Weight304.76800
Flash Point239.2ºC
Exact Mass304.08700
PSA46.53000
LogP4.38680
Vapour Pressure1.03E-09mmHg at 25°C
Index of Refraction1.573
InChIKeyUGOFYAXVVVXMQT-UHFFFAOYSA-N
SMILESCC(C)(OCc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)O
Storage condition2-8℃

Safety Information

HS Code2918990090

Customs

HS Code2918990090
Summary2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Clobuzaritum [INN-Latin]
Clobuzarit
EINECS 245-035-4
2-[[p-(p-chlorophenyl)benzyl]oxy]-2-methylpropionic acid
2-((4'-Chloro-4-biphenylyl)methoxy)-2-methylpropionic acid
Clobuzaritum
2-{[(4'-chlorobiphenyl-4-yl)methyl]oxy}-2-methylpropanoic acid
Propanoic acid,2-((4'-chloro(1,1'-biphenyl)-4-yl)methoxy)-2-methyl
2-[4-(4-chlorophenyl)benzyloxy]-2-methylpropionic acid
Clozic
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