Introduction：Basic information about CAS 1096708-71-2|MLN 2480, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MLN 2480 |
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| CAS Number | 1096708-71-2 | Molecular Weight | 506.28900 |
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| Density | 1.64 | Boiling Point | / |
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| Molecular Formula | C17H12Cl2F3N7O2S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | mln2480 |
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| Synonym | More Synonyms |
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MLN 2480 BiologicalActivity
| Description | MLN 2480 is an orally active and selective inhibitor of pan-Raf kinase. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | RAF |
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| In Vitro | MLN2480 has effect on reversing feedback activation of MEK in response to TAK-733, leading to more concerted MAPK pathway inhibition[1]. |
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| In Vivo | MLN2480 inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinical cancer models at concentrations that are tolerated in vivo. MLN2480 is most potent in BRAF mutant melanoma models but also has single agent activity in some RAS mutant models. The combination of MLN2480 with TAK-733 inhibits the growth of a broader range of RAS mutant tumor models than single agent MLN2480, including primary human tumor xenograft models of melanoma and CRC[1]. |
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| References | [1]. Elizabeth Grace Carideo Cunniff, et al. Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of |
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Chemical & Physical Properties
| Density | 1.64 |
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| Molecular Formula | C17H12Cl2F3N7O2S |
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| Molecular Weight | 506.28900 |
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| Exact Mass | 505.01000 |
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| PSA | 164.02000 |
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| LogP | 5.02430 |
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| InChIKey | VWMJHAFYPMOMGF-ZCFIWIBFSA-N |
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| SMILES | CC(NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1 |
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| Storage condition | -20℃ |
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Synonyms
| (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide |
| 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide |
| BIIB024 |
| CS-0751 |
| MLN 2480 |
