CAS 6028-07-5|Harmidol hydrochloride

Introduction：Basic information about CAS 6028-07-5|Harmidol hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Harmidol hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Harmidol hydrochloride
CAS Number	6028-07-5	Molecular Weight	236.69700
Density	/	Boiling Point	507.5ºC at 760 mmHg
Molecular Formula	C₁₂H₁₃ClN₂O	Melting Point	265-268ºC (dec.)
MSDS	/	Flash Point	231ºC

Names

Name	harmalol hcl
Synonym	More Synonyms

Harmidol hydrochloride BiologicalActivity

Description	Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. El Gendy MA, et al. Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food Chem Toxicol. 2012;50(2):353-362.

Chemical & Physical Properties

Boiling Point	507.5ºC at 760 mmHg
Melting Point	265-268ºC (dec.)
Molecular Formula	C₁₂H₁₃ClN₂O
Molecular Weight	236.69700
Flash Point	231ºC
Exact Mass	236.07200
PSA	48.38000
LogP	2.47620
InChIKey	BSWAWVOHMZNXOS-UHFFFAOYSA-N
SMILES	CC1=NCCc2c1[nH]c1cc(O)ccc21.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1047000

CHEMICAL NAME :: 3H-Pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl-, monohydrochloride

CAS REGISTRY NUMBER :: 6028-07-5

LAST UPDATED :: 198608

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H12-N2-O.Cl-H

MOLECULAR WEIGHT :: 236.72

WISWESSER LINE NOTATION :: T656 BM EN DUT&&J D1 LQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03207

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

Safety Information

HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

harmalol dihydrochloride

HARMALOL HYDROCHLORIDE

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