Introduction：Basic information about CAS 520-11-6|6-Methoxyluteolin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 6-Methoxyluteolin |
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| CAS Number | 520-11-6 | Molecular Weight | 316.262 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 659.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O7 | Melting Point | 267ºC |
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| MSDS | / | Flash Point | 250.9±25.0 °C |
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Names
| Name | 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one |
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| Synonym | More Synonyms |
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6-Methoxyluteolin BiologicalActivity
| Description | Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>Others |
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| In Vitro | Pretreatment with Nepetin dose-dependently inhibited IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43, 3.42 and 4.17 μM, respectively[1]. Nepetin (2.5-10 μM; 25 hours; ARPE-19 cells) treatment suppresses IL-1β-induced cytokine (IL-6, IL-8 and MCP-1) expression at mRNA level in ARPE-19 cells[1]. Nepetin (2.5-10 μM; 1.5 hours; ARPE-19 cells) treatment dose-dependently inhibits phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Nepetin decreases the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells[1]. RT-PCR[1] Cell Line: ARPE-19 cells Concentration: 2.5 μM, 5 μM, 10 μM Incubation Time: 25 hours Result: Suppressed the mRNA expression of IL-6, IL-8 and MCP-1 in ARPE-19 cells. Western Blot Analysis[1] Cell Line: ARPE-19 cells Concentration: 2.5 μM, 5 μM, 10 μM Incubation Time: 1.5 hours Result: Dose-dependently inhibited phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Decreased the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells. |
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| References | [1]. Chen X, et al. Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells. Biomed Pharmacother. 2018 May;101:87-93. [2]. Militão GC, et al. Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK. Pharmazie. 2004 Dec;59(12):965-6. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 659.1±55.0 °C at 760 mmHg |
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| Melting Point | 267ºC |
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| Molecular Formula | C16H12O7 |
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| Molecular Weight | 316.262 |
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| Flash Point | 250.9±25.0 °C |
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| Exact Mass | 316.058289 |
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| PSA | 120.36000 |
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| LogP | 1.89 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.727 |
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| InChIKey | FHHSEFRSDKWJKJ-UHFFFAOYSA-N |
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| SMILES | COc1c(O)cc2oc(-c3ccc(O)c(O)c3)cc(=O)c2c1O |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5,7,3',4'-Tetrahydroxy-6-methoxyflavone |
| Flavone, 3',4',5,7-tetrahydroxy-6-methoxy- |
| Nepetin |
| 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy- |
| 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one |
| 3',4',5,7-Tetrahydroxy-6-methoxyflavone |
| 6-METHOXYLUTEOLIN |
| Eupafolin |
| 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one |
