Introduction：Basic information about CAS 60117-24-0|Leu-Enkephalin amide acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Leu-Enkephalin amide acetate salt |
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| CAS Number | 60117-24-0 | Molecular Weight | 554.63800 |
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| Density | 1.254 g/cm3 | Boiling Point | 1012.8ºC at 760 mmHg |
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| Molecular Formula | C28H38N6O6 | Melting Point | / |
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| MSDS | / | Flash Point | 566.3ºC |
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Names
| Name | 2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide |
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| Synonym | More Synonyms |
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Leu-Enkephalin amide acetate salt BiologicalActivity
| Description | [Leu5]-Enkephalin, amide is a δ opioid receptor agonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorPeptidesResearch Areas >>Neurological Disease |
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| Target | δ opioid receptor[1] |
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| In Vitro | [Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.1 nM[2]. |
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| In Vivo | Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1]. |
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| References | [1]. Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. |
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Chemical & Physical Properties
| Density | 1.254 g/cm3 |
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| Boiling Point | 1012.8ºC at 760 mmHg |
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| Molecular Formula | C28H38N6O6 |
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| Molecular Weight | 554.63800 |
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| Flash Point | 566.3ºC |
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| Exact Mass | 554.28500 |
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| PSA | 205.74000 |
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| LogP | 2.20230 |
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| Index of Refraction | 1.586 |
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| InChIKey | YZXGODHVAJPXSG-UHFFFAOYSA-N |
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| SMILES | CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(N)=O |
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Synonyms
| Leu-enkephalinamide |
| Leu-enkephalin |
| Tyr-Gly-Gly-Phe-Leu-NH2 |
| H-YGGFL-NH2 |
| Enkephalinamide-leu |
| leucine-enkephalin amide |
| tyrosylglycylglycylphenylalanylleucinamide |
| [Leu5]-Enkephalin, amide |
