Introduction：Basic information about CAS 239101-33-8|Deferitrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Deferitrin |
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| CAS Number | 239101-33-8 | Molecular Weight | 253.274 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 525.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C11H11NO4S | Melting Point | / |
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| MSDS | / | Flash Point | 271.8±32.9 °C |
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Names
| Name | (2Z,4S)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-1,3-thiazolidine-4-carboxylic acid |
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| Synonym | More Synonyms |
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Deferitrin BiologicalActivity
| Description | Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vitro | The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 µmol/kg is shown to be 1.1%[1]. |
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| References | [1]. Raymond J Bergeron, et al. Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues. J Med Chem. 2008 Jul 10;51(13):3913-23. [2]. Joanne M Donovan, et al. Preclinical and Clinical Development of Deferitrin, a Novel, Orally Available Iron Chelator. Ann N Y Acad Sci. 2005;1054:492-4. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 525.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C11H11NO4S |
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| Molecular Weight | 253.274 |
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| Flash Point | 271.8±32.9 °C |
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| Exact Mass | 253.040878 |
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| PSA | 115.42000 |
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| LogP | -0.13 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.683 |
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| InChIKey | OEUUFNIKLCFNLN-LLVKDONJSA-N |
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| SMILES | CC1(C(=O)O)CSC(c2ccc(O)cc2O)=N1 |
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Synonyms
| (4S)-2-(2,4-Dihydroxyphenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid |
| 4'-Hydroxydesazadesferrithiocin |
| GT 56-252 |
| 4-Thiazolecarboxylic acid, 2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-, (4S)- |
| UNII-T69Y9LDN44 |
| Deferitrin |
