Introduction：Basic information about CAS 4199-88-6|5-Nitro-1,10-phenanthroline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Nitro-1,10-phenanthroline |
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| CAS Number | 4199-88-6 | Molecular Weight | 225.203 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 444.0±30.0 °C at 760 mmHg |
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| Molecular Formula | C12H7N3O2 | Melting Point | 202-204 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 222.3±24.6 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 5-Nitro-1,10-phenanthroline |
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| Synonym | More Synonyms |
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5-Nitro-1,10-phenanthroline BiologicalActivity
| Description | 5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1]. |
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| Related Catalog | Research Areas >>Infection |
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| In Vitro | 5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages[2]. 5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb[2]. Cell Viability Assay[2] Cell Line: Mtb H37Rv, M. bovis BCG and M. bovis BCG-5NP resistant strain Concentration: 0-12.5 μM Incubation Time: 24 hours Result: Inhibited pathogens with MIC99 values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovis BCG), and >12.5 μM (M. bovis BCG-5NP), respectively. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 444.0±30.0 °C at 760 mmHg |
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| Melting Point | 202-204 °C(lit.) |
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| Molecular Formula | C12H7N3O2 |
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| Molecular Weight | 225.203 |
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| Flash Point | 222.3±24.6 °C |
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| Exact Mass | 225.053833 |
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| PSA | 71.60000 |
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| LogP | 1.56 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.768 |
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| InChIKey | PDDBTWXLNJNICS-UHFFFAOYSA-N |
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| SMILES | O=[N+]([O-])c1cc2cccnc2c2ncccc12 |
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| Water Solubility | insoluble |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xn: Harmful;Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles1
More Articles
| The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators. J. Inorg. Biochem. 101 , 1049-1058, (2007) Fifteen platinum(II)-based metallointercalators have been synthesised that utilise substituted 1,10-phenanthroline (phen) ligands, including 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10-phe... | |
Synonyms
| 5-nitro-1,10-phenenthroline |
| 1,10-Phenanthroline, 5-nitro- |
| 5-Nitro-1,10-phenanthroline |
| 5-Nitro-1,10-diazaphenanthrene |
| EINECS 224-097-6 |
| 5-nitro-1,10-phenantroline |
| 1,10-Phenanthroline,5-nitro |
| Nitroferroin |
| MFCD00004981 |
