Introduction：Basic information about CAS 220998-10-7|elomotecan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | elomotecan |
|---|
| CAS Number | 220998-10-7 | Molecular Weight | 522.035 |
|---|
| Density | 1.4±0.1 g/cm3 | Boiling Point | 821.3±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C29H32ClN3O4 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 450.5±34.3 °C |
|---|
Names
| Name | Elomotecan |
|---|
| Synonym | More Synonyms |
|---|
elomotecan BiologicalActivity
| Description | Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II. Elomotecan is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan reduces the proliferation of different tumor cells with higher potency than other anticancer drugs of reference targeting topoisomerases I and II[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Topoisomerase |
|---|
| Target | Topoisomerase I Topoisomerase II |
|---|
| References | [1]. Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250. |
|---|
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|
| Boiling Point | 821.3±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C29H32ClN3O4 |
|---|
| Molecular Weight | 522.035 |
|---|
| Flash Point | 450.5±34.3 °C |
|---|
| Exact Mass | 521.208130 |
|---|
| PSA | 84.66000 |
|---|
| LogP | 3.98 |
|---|
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
|---|
| Index of Refraction | 1.684 |
|---|
| InChIKey | KAQREZSTQZWNAG-GDLZYMKVSA-N |
|---|
| SMILES | CCC1(O)CC(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc(Cl)c(C)cc1c2CN1CCC(C)CC1 |
|---|
Synonyms
| 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 9-chloro-5-ethyl-1,4,5,13-tetrahydro-5-hydroxy-10-methyl-12-[(4-methyl-1-piperidinyl)methyl]-, (5R)- |
| unii-44ka9q75gt |
| elomotecan |
| (5R)-9-Chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methyl-1-piperidinyl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione |
