Introduction：Basic information about CAS 1093861-60-9|Afoxolaner, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Afoxolaner |
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| CAS Number | 1093861-60-9 | Molecular Weight | 625.87000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H17ClF9N3O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | afoxolaner |
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| Synonym | More Synonyms |
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Afoxolaner BiologicalActivity
| Description | Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Chloride ChannelResearch Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| In Vivo | A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1]. |
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| References | [1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5. [2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42. |
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Chemical & Physical Properties
| Molecular Formula | C26H17ClF9N3O3 |
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| Molecular Weight | 625.87000 |
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| Exact Mass | 625.08100 |
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| PSA | 79.79000 |
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| LogP | 6.71990 |
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| InChIKey | OXDDDHGGRFRLEE-UHFFFAOYSA-N |
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| SMILES | O=C(CNC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)c2ccccc12)NCC(F)(F)F |
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Synonyms
| 4-[(5R)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide |
| 4-[(5RS)-5-(5-chloro-α,α,α-trifluoro-m-tolyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide |
| UNII-02L07H6D0U |
| rac-4-{(5R)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl}-N-{2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}naphthalene-1-carboxamide |
| 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide |
| Afoxolaner |
