CAS 482-25-7|Byakangelicin
| Common Name | Byakangelicin | ||
|---|---|---|---|
| CAS Number | 482-25-7 | Molecular Weight | 334.321 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 571.5±50.0 °C at 760 mmHg |
| Molecular Formula | C17H18O7 | Melting Point | 123-124℃ |
| MSDS | ChineseUSA | Flash Point | 299.4±30.1 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Byakangelicin |
|---|---|
| Synonym | More Synonyms |
Byakangelicin BiologicalActivity
| Description | Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| Target | PXR[2] |
| References | [1]. Kang YY, et al. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine. 2019 May 17;62:152963. [2]. Yang J, et al. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Br J Pharmacol. 2011 Jan;162(2):441-51. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 571.5±50.0 °C at 760 mmHg |
| Melting Point | 123-124℃ |
| Molecular Formula | C17H18O7 |
| Molecular Weight | 334.321 |
| Flash Point | 299.4±30.1 °C |
| Exact Mass | 334.105255 |
| PSA | 102.27000 |
| LogP | 1.62 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.613 |
| InChIKey | PKRPFNXROFUNDE-LLVKDONJSA-N |
| SMILES | COc1c2ccoc2c(OCC(O)C(C)(C)O)c2oc(=O)ccc12 |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
Articles6
More Articles| Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001) A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone... | |
| [Studies on quality standards of radix Angelicae dahuricae]. Zhongguo Zhong Yao Za Zhi 29(7) , 654-7, (2004) To work out a qualitay standard of Radix Angelicae dahuricae.TLC and HPLC were adopted.Four coumerin compounds were identified by TLC, and the contents of two compounds were determined by HPLC.Imperat... | |
| Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 68(5) , 463-4, (2002) Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4)... |
Synonyms
| 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxy- |
| 9-[(2R)-2,3-Dihydroxy-3-methylbutoxy]-4-methoxy-7H-furo[3,2-g]chromen-7-one |
