Introduction：Basic information about CAS 935467-97-3|TH-237A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TH-237A |
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| CAS Number | 935467-97-3 | Molecular Weight | 333.329 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 455.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H17F2NO3 | Melting Point | 90 °C (hexane) |
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| MSDS | / | Flash Point | 229.3±28.7 °C |
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Names
| Name | 1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-rel |
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| Synonym | More Synonyms |
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TH-237A BiologicalActivity
| Description | TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier.IC50 value: 5 nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides)Target: Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| References | [1]. Kelly E. Desino, Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 455.5±45.0 °C at 760 mmHg |
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| Melting Point | 90 °C (hexane) |
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| Molecular Formula | C18H17F2NO3 |
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| Molecular Weight | 333.329 |
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| Flash Point | 229.3±28.7 °C |
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| Exact Mass | 333.117645 |
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| PSA | 41.93000 |
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| LogP | 4.40 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.626 |
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| InChIKey | AEZQGSQEXPUADE-JWTNVVGKSA-N |
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| SMILES | OCC12COC(c3ccc(F)cc3)N1C(c1ccc(F)cc1)OC2 |
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| Storage condition | 2-8℃ |
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Synonyms
| TH 237A |
| [(3R,5S)-3,5-Bis(4-fluorophenyl)-1H-[1,3]oxazolo[3,4-c][1,3]oxazol-7a(7H)-yl]methanol |
| (3R,5S,7as)-[3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl]methanol |
| 1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)- |
| meso-GS 164 |
| TH-237A |
