CAS 81093-37-0|Pravastatin

Introduction：Basic information about CAS 81093-37-0|Pravastatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pravastatin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Pravastatin
CAS Number	81093-37-0	Molecular Weight	424.53
Density	1.2±0.1 g/cm3	Boiling Point	634.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₆O₇	Melting Point	171.2-173ºC
MSDS	/	Flash Point	213.2±25.0 °C

Names

Name	pravastatin
Synonym	More Synonyms

Pravastatin BiologicalActivity

Description	Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.Target: HMG-CoA reductasePravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease.Pravastatin is primarily used for the treatment of dyslipidemia and the prevention of cardiovascular disease. It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.The evidence for the use of pravastatin is generally weaker than for other statins. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT), failed to demonstrate a difference in all-cause mortality or nonfatal myocardial infarction/fatal coronary heart disease rates between patients receiving pravastatin 40mg daily (a common starting dose) and those receiving usual care.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Research Areas >>Cardiovascular Disease
References	[1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	634.5±55.0 °C at 760 mmHg
Melting Point	171.2-173ºC
Molecular Formula	C₂₃H₃₆O₇
Molecular Weight	424.53
Flash Point	213.2±25.0 °C
PSA	127.12000
LogP	1.35
Vapour Pressure	0.0±4.2 mmHg at 25°C
Index of Refraction	1.555
InChIKey	TUZYXOIXSAXUGO-PZAWKZKUSA-N
SMILES	CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC(=O)O)C21
Storage condition	2-8°C
Water Solubility	H2O: 19 mg/mL

Safety Information

Hazard Codes	F: Flammable;C: Corrosive;
Risk Phrases	R11;R34
Safety Phrases	S16-S26-S36/37/39-S45
WGK Germany	2
RTECS	QJ7185000

Synonyms

(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid

[14C]-Pravastatin

Oliprevin

MFCD00887601

Pravastatina

(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

Pravachol

Pravastatinum

(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

Pravastatin

[3H]-Pravastatin

Pravastatine [French]

Pravastatina [Spanish]

1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (βR,δR,1S,2S,6S,8S,8aR)-

(3R,5R)-3,5-dihydroxy-7-{(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyloxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}heptanoic acid

Pravastatine

Pravastatinum [Latin]

Eptastatin

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