CAS 106133-20-4|Tamsulosin

Introduction：Basic information about CAS 106133-20-4|Tamsulosin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tamsulosin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Tamsulosin
CAS Number	106133-20-4	Molecular Weight	408.512
Density	1.2±0.1 g/cm3	Boiling Point	595.5±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈N₂O₅S	Melting Point	226-228ºC
MSDS	/	Flash Point	313.9±32.9 °C

Names

Name	tamsulosin
Synonym	More Synonyms

Tamsulosin BiologicalActivity

Description	Tamsulosin is a selective α1 receptor antagonist.Target: α1 receptorTamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels. Tamsulosin-treated patients had a 0.30-fold lower risk of developing acute urinary retention compared with control patients. None of the International Continence Society male questionnaire domain scores showed significant changes between the groups [1]. tamsulosin can be recommended for treating men after catheterization for AUR, and can reduce the likelihood of the need for re-catheterization [2].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease
References	[1]. Jeong, I.G., et al., Impact of tamsulosin on urinary retention following early catheter removal after robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled trial. Int J Urol, 2014. 21(2): p. 164-8. [2]. Lucas, M.G., T.P. Stephenson, and V. Nargund, Tamsulosin in the management of patients in acute urinary retention from benign prostatic hyperplasia. BJU Int, 2005. 95(3): p. 354-7.

Description

Tamsulosin is a selective α1 receptor antagonist.Target: α1 receptorTamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels. Tamsulosin-treated patients had a 0.30-fold lower risk of developing acute urinary retention compared with control patients. None of the International Continence Society male questionnaire domain scores showed significant changes between the groups [1]. tamsulosin can be recommended for treating men after catheterization for AUR, and can reduce the likelihood of the need for re-catheterization [2].

Related Catalog

Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease

References

[1]. Jeong, I.G., et al., Impact of tamsulosin on urinary retention following early catheter removal after robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled trial. Int J Urol, 2014. 21(2): p. 164-8.

[2]. Lucas, M.G., T.P. Stephenson, and V. Nargund, Tamsulosin in the management of patients in acute urinary retention from benign prostatic hyperplasia. BJU Int, 2005. 95(3): p. 354-7.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	595.5±60.0 °C at 760 mmHg
Melting Point	226-228ºC
Molecular Formula	C₂₀H₂₈N₂O₅S
Molecular Weight	408.512
Flash Point	313.9±32.9 °C
Exact Mass	408.171906
PSA	108.26000
LogP	2.24
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.553
InChIKey	DRHKJLXJIQTDTD-OAHLLOKOSA-N
SMILES	CCOc1ccccc1OCCNC(C)Cc1ccc(OC)c(S(N)(=O)=O)c1

Safety Information

HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Synonyms

amsulosin

Flomax

Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-

Tamsulosinum

5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide

[14C]-Tamsulosin

(R)-5-[2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide

Tamsulosine

Tamsulosina

5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide

Tamsulosin

Tamsolusin

MFCD00871531

Tamsulosina [INN-Spanish]

Tamsulosine [INN-French]

(R)-(-)-5-[2-(2-(2-ethoxyphenoxy)ethylamino)propyl]-2-methoxybenzenesulfonamide

5-[(2R)-2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide

Tamsulosinum [INN-Latin]

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