Introduction：Basic information about CAS 89365-50-4|Salmeterol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Salmeterol |
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| CAS Number | 89365-50-4 | Molecular Weight | 415.566 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 603.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H37NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 318.5±31.5 °C |
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Names
| Name | 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol |
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| Synonym | More Synonyms |
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Salmeterol BiologicalActivity
| Description | Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma.Target: beta2-Adrenergic ReceptorSalmeterol is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma and chronic obstructive pulmonary disease (COPD). salmeterol also binds with very high affinity at a second site, termed the "exosite", and that this exosite contributes to the long duration of action of salmeterol [1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Others |
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| References | [1]. Rong, Y., et al., Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol. Biochemistry, 1999. 38(35): p. 11278-86. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 603.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H37NO4 |
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| Molecular Weight | 415.566 |
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| Flash Point | 318.5±31.5 °C |
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| Exact Mass | 415.272247 |
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| PSA | 81.95000 |
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| LogP | 3.07 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.566 |
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| InChIKey | GIIZNNXWQWCKIB-UHFFFAOYSA-N |
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| SMILES | OCc1cc(C(O)CNCCCCCCOCCCCc2ccccc2)ccc1O |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CZ6457000
- CHEMICAL NAME :
- 1,3-Benzenedimethanol, 4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)met hyl)-, (+-)-
- CAS REGISTRY NUMBER :
- 89365-50-4
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C25-H37-N-O4
- MOLECULAR WEIGHT :
- 415.63
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5600 ug/kg/28D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in spleen Immunological Including Allergic - decreased immune response
- REFERENCE :
- IJIMDS International Journal of Immunopharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979- Volume(issue)/page/year: 18,523,1996
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Safety Information
| RTECS | CZ6457000 |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (+-)-4-hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedi |
| SAMETEROL |
| SalmeterolXenofoate |
| 4-Hydroxy-3-[hydroxymethyl]phenyl-N-[6-phenylbutoxyhexyl]ethanolamine |
| Salmeterol |
| 2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol |
| 2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol |
| 2-hydroxymethyl-4-{1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl}phenol |
| (±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol |
| MFCD00867037 |
| serevent (R) |
| (±)-4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-m-xylene-a,a1-diol |
| 1,3-Benzenedimethanol, 4-hydroxy-α-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]- |
| SALMETEROL(SUBJECTTOPATENTFREE) |
| 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL |
