Introduction：Basic information about CAS 115074-43-6|Mupirocin calcium hydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mupirocin calcium hydrate |
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| CAS Number | 115074-43-6 | Molecular Weight | 1075.34000 |
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| Density | / | Boiling Point | 672.3ºC at 760 mmHg |
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| Molecular Formula | C26H44O9.1/2Ca.H2O | Melting Point | / |
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| MSDS | / | Flash Point | 216.5ºC |
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Names
| Name | mupirocin calcium, reference spectrum ep standard |
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| Synonym | More Synonyms |
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Mupirocin calcium hydrate BiologicalActivity
| Description | Mupirocin calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Mupirocin Calcium Salt shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin Calcium Salt is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum[1]. |
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| In Vivo | Mupirocin Calcium Salt is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1]. |
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| References | [1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8. [2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70. |
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Chemical & Physical Properties
| Boiling Point | 672.3ºC at 760 mmHg |
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| Molecular Formula | C26H44O9.1/2Ca.H2O |
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| Molecular Weight | 1075.34000 |
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| Flash Point | 216.5ºC |
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| Exact Mass | 1074.57000 |
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| PSA | 288.56000 |
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| LogP | 4.90220 |
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| Vapour Pressure | 5.91E-21mmHg at 25°C |
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| InChIKey | DDHVILIIHBIMQU-YJGQQKNPSA-L |
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| SMILES | CC(=CC(=O)OCCCCCCCCC(=O)[O-])CC1OCC(CC2OC2C(C)C(C)O)C(O)C1O.CC(=CC(=O)OCCCCCCCCC(=O)[O-])CC1OCC(CC2OC2C(C)C(C)O)C(O)C1O.O.O.[Ca+2] |
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| Storage condition | -20℃ |
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| Water Solubility | Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride. |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Mupirocin calcium dihydrate |
| Unii-rg38I2p540 |
| MupirocinCalcium |
| mupirocin calcium hydrate |
| Calcium mupirocin dihydrate |
| Mupirocin Calcium Salt |
