Introduction：Basic information about CAS 22818-40-2|(D)-(-)-α-4-hydroxyphenyl glycine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (D)-(-)-α-4-hydroxyphenyl glycine |
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| CAS Number | 22818-40-2 | Molecular Weight | 167.162 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 365.8±32.0 °C at 760 mmHg |
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| Molecular Formula | C8H9NO3 | Melting Point | 240 °C (dec.)(lit.) |
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| MSDS | ChineseUSA | Flash Point | 175.0±25.1 °C |
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Names
| Name | D-4-hydroxyphenylglycine |
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| Synonym | More Synonyms |
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(D)-(-)-α-4-hydroxyphenyl glycine BiologicalActivity
| Description | D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Yu H, et al. Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii. Folia Microbiol (Praha). 2009;54(6):509-515. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 365.8±32.0 °C at 760 mmHg |
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| Melting Point | 240 °C (dec.)(lit.) |
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| Molecular Formula | C8H9NO3 |
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| Molecular Weight | 167.162 |
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| Flash Point | 175.0±25.1 °C |
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| Exact Mass | 167.058243 |
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| PSA | 83.55000 |
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| LogP | 0.20 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.633 |
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| InChIKey | LJCWONGJFPCTTL-SSDOTTSWSA-N |
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| SMILES | NC(C(=O)O)c1ccc(O)cc1 |
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| Water Solubility | 5 g/L (20 ºC) |
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Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi:Irritant |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 29225000 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (D)-(-)-α-4-hydroxyphenyl glycine |
| (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine |
| D(-)-2-amino-(4-hydroxyphenyl)acetic acid |
| (R)-2-(4-Hydroxyphenyl)glycine |
| (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine,Cefadroxyl impurity A |
| D(-)-4-Hydroxyphenylglycine |
| Benzeneacetic acid, α-amino-4-hydroxy-, (αR)- |
| (2R)-2-Amino-2-(4 |
| D-N-(4-Hydroxyphenyl)glycine |
| (2R)-Amino(4-hydroxyphenyl)acetic acid |
| D(-)-2-(4-hydroxyphenyl)glycine |
| (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| EINECS 245-247-7 |
| MFCD00004262 |
| (2R)-2-amino-2-(4-hydroxyphenyl)acetic acid |
| H-D-Phg(4-OH)-OH |
| (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| D-(-)-2-(4-Hydroxyphenyl)glycine |
| 4-Hydroxy-D-phenylglycine |
| 4-Hydroxy-D-(-)-2-phenylglycine |
| (D)-(-)-Alfa-4-hydroxyphenyl glycine |
| (R)-para-hydroxyphenylglycine |
| Amoxicillin Impurity 8 |
