CAS 948-71-0|5-hydroxy Thiabendazole
| Common Name | 5-hydroxy Thiabendazole | ||
|---|---|---|---|
| CAS Number | 948-71-0 | Molecular Weight | 217.25 |
| Density | 1.535g/cm3 | Boiling Point | 525.6ºC at 760mmHg |
| Molecular Formula | C10H7N3OS | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 271.7ºC |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | 5-Hydroxy Thiabendazole |
|---|---|
| Synonym | More Synonyms |
5-hydroxy Thiabendazole BiologicalActivity
| Description | 5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure[1]. |
|---|---|
| Related Catalog | Research Areas >>Others |
| References | [1]. STONE OJ, et al. COMPARISON OF THIABENDAZOLE AND 5-HYDROXY-THIABENDAZOLE (FOR ANTHELMINTIC EFFECT). J Invest Dermatol. 1965 Aug;45:132-3. |
Chemical & Physical Properties
| Density | 1.535g/cm3 |
|---|---|
| Boiling Point | 525.6ºC at 760mmHg |
| Molecular Formula | C10H7N3OS |
| Molecular Weight | 217.25 |
| Flash Point | 271.7ºC |
| Exact Mass | 217.03100 |
| PSA | 90.04000 |
| LogP | 2.39200 |
| Index of Refraction | 1.783 |
| InChIKey | VNENJHUOPQAPAT-UHFFFAOYSA-N |
| SMILES | Oc1ccc2nc(-c3cscn3)[nH]c2c1 |
| Storage condition | 0-6°C |
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn,N |
| Risk Phrases | 22-50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 |
| Packaging Group | III |
| Hazard Class | 9 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles16
More Articles| Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry. J. AOAC Int. 98(1) , 230-47, (2015) Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using ... | |
| Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells. Chem. Biol. Interact. 127(2) , 109-24, (2000) Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazol... | |
| In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions. Drug Metab. Dispos. 37 , 1286-1294, (2009) Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence ... |
Synonyms
| 2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-ol |
