CAS 328-50-7|2-Ketoglutaric acid
| Common Name | 2-Ketoglutaric acid | ||
|---|---|---|---|
| CAS Number | 328-50-7 | Molecular Weight | 146.098 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 345.6±25.0 °C at 760 mmHg |
| Molecular Formula | C5H6O5 | Melting Point | 113-115 °C |
| MSDS | ChineseUSA | Flash Point | 177.0±19.7 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | 2-oxoglutaric acid |
|---|---|
| Synonym | More Synonyms |
2-Ketoglutaric acid BiologicalActivity
| Description | 2-Ketoglutaric acid is an intermediate compound of the Krebs cycle and is also connected to glutamic acid and glutamine metabolisms through the transamination reactions. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Rocchiccioli F, et al. Microdetermination of 2-ketoglutaric acid in plasma and cerebrospinal fluid by capillary gas chromatography mass spectrometry; application to pediatrics. Biomed Mass Spectrom. 1984 Jan;11(1):24-8. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 345.6±25.0 °C at 760 mmHg |
| Melting Point | 113-115 °C |
| Molecular Formula | C5H6O5 |
| Molecular Weight | 146.098 |
| Flash Point | 177.0±19.7 °C |
| Exact Mass | 146.021530 |
| PSA | 91.67000 |
| LogP | -1.43 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.494 |
| InChIKey | KPGXRSRHYNQIFN-UHFFFAOYSA-N |
| SMILES | O=C(O)CCC(=O)C(=O)O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280-P305 + P351 + P338 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi,T |
| Risk Phrases | R37/38:Irritating to respiratory system and skin . R41:Risk of serious damage to eyes. R36/37/38:Irritating to eyes, respiratory system and skin . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S26-S39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29183000 |
Customs
| HS Code | 2918300090 |
|---|---|
| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles74
More Articles| Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography. J. Chromatogr. A. 1361 , 265-76, (2014) This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u... | |
| Physiology and pathophysiology of organic acids in cerebrospinal fluid. J. Inherit. Metab. Dis. 16(4) , 648-69, (1993) Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo... | |
| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin. Chem. 40(6) , 862-6, (1994) Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days... |
Synonyms
| 2-oxopentanedionic acid |
| ketoglutaric acid |
| EINECS 206-330-3 |
| α-Oxoglutaric acid |
| FEMA 3891 |
| Pentanedioic acid, 2-oxo- (9CI) |
| α-Oxopentanedioic acid |
| α-Ketoglutaric acid |
| A-KETOGLUTARIC ACID |
| 2-Oxo-Glutaric Acid |
| 2-Oxoglutaric acid,2-Oxopentanedioic acid |
| 2-Oxoglutaric Acid |
| MFCD00004165 |
| OXOGLUTARIC ACID |
| KETO-GLU |
| Pentanedioic acid, 2-oxo- |
| 2-Ketoglutaric acid |
| 2-Oxopentanedioic acid |
| Glutaric acid, 2-oxo- (8CI) |
| α-keto-Glutaric acid |
| Glutaric acid, 2-oxo- |
| 2-Oxo-1,5-pentanedioic acid |
| Alphaketoglutaric acid |
