Introduction：Basic information about CAS 62669-70-9|Rhodamine 123, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rhodamine 123 |
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| CAS Number | 62669-70-9 | Molecular Weight | 380.824 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H17ClN2O3 | Melting Point | 235 °C |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | rhodamine 123 |
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| Synonym | More Synonyms |
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Rhodamine 123 BiologicalActivity
| Description | Rhodamine 123 is a fluorescent dye (λex=503 nm, λem=527 nm). |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular DiseaseDye Reagents |
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| In Vitro | The intensity of R123 fluorescence has a peak at concentration of 50 μM, and decreases to zero at higher concentrations due to self-quenching[1]. |
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| Kinase Assay | Measurements are made at room temperature with continuous stirring of the mitochondrial suspension using spectrophotometer equipped with a magnetic stirrer with fluorescent cation R123 as probe. Excitation and emission wavelengths are 503 nm and 527 nm, respectively. The incubation medium is the respiration buffer. R123 and sodium pyruvate are added to final concentrations of 50 nM and 10 mM, respectively. Isolated mitochondria maintain a steady membrane potential (±5%) throughout the duration of the recording[1]. |
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| References | [1]. M. Huang, et al. Mitochondrial Inner Membrane Electrophysiology Assessed by Rhodamine-123 Transport and Fluorescence. Ann Biomed Eng. 2007 Jul; 35(7): 1276–1285. |
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Chemical & Physical Properties
| Melting Point | 235 °C |
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| Molecular Formula | C21H17ClN2O3 |
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| Molecular Weight | 380.824 |
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| Exact Mass | 380.092773 |
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| PSA | 89.31000 |
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| LogP | 5.53580 |
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| InChIKey | SEXIURXGNASJRB-UHFFFAOYSA-N |
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| SMILES | COC(=O)c1ccccc1-c1c2ccc(=N)cc-2oc2cc(N)ccc12.Cl.O |
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| Water Solubility | Partially soluble |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- ZE0883000
- CHEMICAL NAME :
- Xanthylium, 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)-, chloride
- CAS REGISTRY NUMBER :
- 62669-70-9
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H17-N2-O3.Cl
- MOLECULAR WEIGHT :
- 380.85
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 7-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 9,29,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 7-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 40,143,1989
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R22 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | ZE0883000 |
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| HS Code | 2932999099 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| RHODAMINE METHYL ESTER CHLORIDE |
| Xanthylium, 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-, chloride (1:1) |
| 2-(6-amino-3-imino-3H-xanthen-9-yl)-methyl ester,hydrochloride |
| rh123 |
| 3,6-Diamino-9-[2-(methoxycarbonyl)phenyl]xanthenium chloride |
| MFCD00012664 |
| RHODAMINE 123 HYDROCHLORIDE |
| Rhodamine 123 |
| RHODAMINE 123,PURE |
| XANTHYLIUM, 3,6-DIAMINO-9-(2-(METHOXYCARBONYL)PHENYL)-, CHLORIDE |
| rhodamine 110 methyl ester |
| Rhodamine-123 |
| EINECS 263-687-8 |
