CAS 480-40-0|Chrysin
Introduction：Basic information about CAS 480-40-0|Chrysin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chrysin | ||
|---|---|---|---|
| CAS Number | 480-40-0 | Molecular Weight | 254.238 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 491.9±45.0 °C at 760 mmHg |
| Molecular Formula | C15H10O4 | Melting Point | 284-286 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 192.5±22.2 °C |
Names
| Name | chrysin |
|---|---|
| Synonym | More Synonyms |
Chrysin BiologicalActivity
| Description | Chrysin is one of the most well known estrogen blockers. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>CancerNatural Products >>Flavonoids |
| Target | estrogen |
| In Vitro | Chrysin is mainly found in passion flowers, honey, and propolis acts as a potential therapeutic and preventive agent to inhibit proliferation and invasion of various human cancer cells. Although Chrysin has anti-carcinogenic effects in several cancers, little is known about its functional roles in ovarian cancer which shows poor prognosis and chemoresistance to traditional therapeutic agents. Chrysin inhibits ovarian cancer cell proliferation and induced cell death by increasing reactive oxygen species (ROS) production and cytoplasmic Ca2+ levels as well as inducing loss of mitochondrial membrane potential (MMP). Chrysin activates MAPK and PI3K/AKT pathways in ES2 and OV90 cells in concentration-response experiments. Chrysin suppresses tumor growth byregulating canonical Wnt and nuclear factor NF-κB signaling cascades cancer cells. Chrysin stimulates the phosphorylation of AKT and P70S6K proteins in both ES2 and OV90 cells compared tothe untreated control cells. In addition, Chrysin activates the phospho-ERK1/2, p38,and JNK proteins as members of the MAPK pathway in the ovarian cancer cells[1]. |
| Cell Assay | The proliferation assays are conducted using a cell proliferation enzyme-linked immunosorbent assay (ELISA) 5-bromo-2'-deoxyuridine (BrdU) kit. Briefly, ES2 and OV90 cells are seeded in a 96-well plate, and then treated with Chrysin (0, 5, 10, 20, 50, and 100 µM) with or without inhibitors (20 μM LY294002, PI3K/AKT; 10 μM U0126, ERK1/2; 10 μM SP600125, JNK; and 20 μM SB203580, p38) in a final volume of 100 μL/well. Aftera48-h incubation, 10 μM BrdU is added to the cell culture, followed by an additional 2-h incubation at 37°C. After labeling the cells with BrdU, they are fixed and then incubated with the anti-BrdU-peroxidase (POD) working solution for 90 min. The anti-BrdU-POD binds to the BrdU incorporated into newly synthesized cellular DNA and these immune complexes are detected by analyzing their reaction with the 3,3',5,5'-tetramethylbenzidine (TMB) substrate. The absorbance values of the reaction product are measured at 370 and 492 nm using an ELISA reader[1]. |
| References | [1]. Lim W, et al. Chrysin Attenuates Progression of Ovarian Cancer Cells by Regulating Signaling Cascades and Mitochondrial Dysfunction. J Cell Physiol. 2017 Aug 17. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 491.9±45.0 °C at 760 mmHg |
| Melting Point | 284-286 °C(lit.) |
| Molecular Formula | C15H10O4 |
| Molecular Weight | 254.238 |
| Flash Point | 192.5±22.2 °C |
| Exact Mass | 254.057907 |
| PSA | 70.67000 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.699 |
| InChIKey | RTIXKCRFFJGDFG-UHFFFAOYSA-N |
| SMILES | O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12 |
| Storage condition | 0-6°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Fibroblast
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 33,3823,1984
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Fibroblast
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 33,3823,1984
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | LK8329050 |
| HS Code | 2914400090 |
Customs
| HS Code | 2914400090 |
|---|---|
| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 5,7-Dihydroxyflavone |
| Chrysin |
| 5,7-dihydroxy-2-phenylchromen-4-one |
| EINECS 207-549-7 |
| 5,7-Dihydroxy-2-phenyl-4H-chromen-4-one |
| MFCD00006834 |
| Chrysidenon 1438 |
| Chrysinic acid |
| 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl- |
