CAS 5636-83-9|dimethindene

Introduction：Basic information about CAS 5636-83-9|dimethindene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. dimethindene BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	dimethindene
CAS Number	5636-83-9	Molecular Weight	292.41800
Density	1.065 g/cm3	Boiling Point	416.3ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂	Melting Point	50 - 53 °C
MSDS	/	Flash Point	205.6ºC

Names

Name	N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
Synonym	More Synonyms

dimethindene BiologicalActivity

Description	Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium ChannelSignaling Pathways >>GPCR/G Protein >>Histamine Receptor
Target	Human Endogenous Metabolite
In Vitro	Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].
In Vivo	Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1]. Animal Model: C57BL/6 mice with skin WH[1] Dosage: 0.25 mg Administration: intraperitoneal injection; once Result: Delayed skin wound closure as compared to vehicle treated mice.

Chemical & Physical Properties

Density	1.065 g/cm3
Boiling Point	416.3ºC at 760 mmHg
Melting Point	50 - 53 °C
Molecular Formula	C₂₀H₂₄N₂
Molecular Weight	292.41800
Flash Point	205.6ºC
Exact Mass	292.19400
PSA	16.13000
LogP	4.14670
Index of Refraction	1.587
InChIKey	MVMQESMQSYOVGV-UHFFFAOYSA-N
SMILES	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT0800000

CHEMICAL NAME :: Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-

CAS REGISTRY NUMBER :: 5636-83-9

BEILSTEIN REFERENCE NO. :: 0489974

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2

MOLECULAR WEIGHT :: 292.46

WISWESSER LINE NOTATION :: L56 BHJ C2N1&1 DY1&- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 618 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 888 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

Synonyms

Triten

Dimethpyrindene

Dimetindeno

N,N-dimethyl-3-[1-(2-pyridyl)ethyl]inden-2-ethylamine

Dimetindene

dimethyl-{2-[3-(1-pyridin-2-yl-ethyl)-inden-2-yl]-ethyl}-amine

Pecofenil

dimethindene

Dimetindenum

Foristal

Fenistil

Forhistal

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