Introduction：Basic information about CAS 6068-78-6|3',4'-Dihydroxyflavonol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3',4'-Dihydroxyflavonol |
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| CAS Number | 6068-78-6 | Molecular Weight | 270.24 |
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| Density | 1.579g/cm3 | Boiling Point | 508.9ºC at 760 mmHg |
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| Molecular Formula | C15H10O5 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 198ºC |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | 2-(3,4-dihydroxyphenyl)-3-hydroxychromen-4-one |
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| Synonym | More Synonyms |
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3',4'-Dihydroxyflavonol BiologicalActivity
| Description | 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Metabolic Disease |
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| In Vitro | 3',4'-Dihydroxyflavonol (DiOHF) acutely preserves nitric oxide (NO) activity in the presence of elevated reactive oxygen species (ROS). DiOHF improves NO activity in diabetes by reducing Nox2-dependent superoxide production and preventing eNOS uncoupling to improve endothelial function[1]. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized third-order branches of rat mesenteric arteries[2]. |
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| References | [1]. Leo CH, et al. 3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. PLoS One. 2011;6(6):e20813. [2]. Kim HY, et al. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):191-202. |
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Chemical & Physical Properties
| Density | 1.579g/cm3 |
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| Boiling Point | 508.9ºC at 760 mmHg |
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| Molecular Formula | C15H10O5 |
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| Molecular Weight | 270.24 |
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| Flash Point | 198ºC |
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| Exact Mass | 270.05300 |
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| PSA | 90.90000 |
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| LogP | 2.57680 |
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| Index of Refraction | 1.747 |
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| InChIKey | KPGMHZQXQVDYNT-UHFFFAOYSA-N |
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| SMILES | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2ccccc12 |
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301 |
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| Precautionary Statements | P301 + P310 |
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| RIDADR | UN 2811 6.1 / PGIII |
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| HS Code | 2914501900 |
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Customs
| HS Code | 2914501900 |
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| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 3',4'-dihydroxyflavonol |
| 3',4'-Dihydroxyflavonol |
| 3,3',4'-TRIHYDROXYFLAVONE |
| 3,3',4'-trihydroxyflavon |
| 2-(3,4-dihydroxy-phenyl)-3-hydroxy-chromen-4-one |
