CAS 84697-22-3|(+/-)-CIS-3-METHYL-2-PIPERIDINECARBOXYLICACID

Introduction：Basic information about CAS 84697-22-3|(+/-)-CIS-3-METHYL-2-PIPERIDINECARBOXYLICACID, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Synonyms

Common Name	(+/-)-CIS-3-METHYL-2-PIPERIDINECARBOXYLICACID
CAS Number	84697-22-3	Molecular Weight	508.42
Density	1.4g/cm3	Boiling Point	646.7ºC at 760 mmHg
Molecular Formula	C₂₃H₂₃Cl₂N₃O₄S	Melting Point	/
MSDS	/	Flash Point	344.9ºC

Names

Name	(+/-)-ethyl-cis-[4-[[2-(2,4-dichlorophenyl)-2-(1h-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]-methylthio]phenyl]-carbamate hydrochloride
Synonym	More Synonyms

BiologicalActivity

Description	Tubulozole is an orally active synthetic microtubule inhibitor. Tubulozole can be used for the research of tumor[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin
In Vivo	Tubulozole (oral; 160 mg/kg) 在体内具有抗微管和抗肿瘤作用[1]。 Animal Model: Male CDFi (DBA/Px C3H) hybrids (18-22 g)[1]. Dosage: 160 mg/kg Administration: Oral gavage Result: Had anti-microtubular and anti-tumor effect.
References	[1]. Distelmans W, et al. Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. Eur J Cancer Clin Oncol. 1989;25(10):1499-1504.

Chemical & Physical Properties

Density	1.4g/cm3
Boiling Point	646.7ºC at 760 mmHg
Molecular Formula	C₂₃H₂₃Cl₂N₃O₄S
Molecular Weight	508.42
Flash Point	344.9ºC
Exact Mass	543.05500
PSA	99.91000
LogP	6.69400
Index of Refraction	1.64
InChIKey	OGPIBXIQNMQSPY-JPYJTQIMSA-N
SMILES	CCOC(=O)Nc1ccc(SCC2COC(Cn3ccnc3)(c3ccc(Cl)cc3Cl)O2)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EZ4208000

CHEMICAL NAME :: Carbamic acid, (4-(((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethy l)-1,3-dioxolan-4-yl) methyl)thio)phenyl)-, ethyl ester, cis-(+-)-

CAS REGISTRY NUMBER :: 84697-22-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H23-Cl2-N3-O4-S

MOLECULAR WEIGHT :: 508.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 244,95,1990

Synonyms

tubulozole-C hydrochloride

cis-tubulozole

CIS-TUBULOZOLE HYDROCHLORIDE

TUBULOZOLE-C

TubulozolecHCl

tubulazole

TUBULOZOLE

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