CAS 104809-20-3|α,β-Methylene-ATP dilithium

Introduction：Basic information about CAS 104809-20-3|α,β-Methylene-ATP dilithium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. α,β-Methylene-ATP dilithium BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles5
6. Synonyms

Common Name	α,β-Methylene-ATP dilithium
CAS Number	104809-20-3	Molecular Weight	519.09
Density	/	Boiling Point	/
Molecular Formula	C₁₁H₁₈Li₂N₅O₁₂P₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	α,β-Methyleneadenosine 5′-triphosphate lithium salt
Synonym	More Synonyms

α,β-Methylene-ATP dilithium BiologicalActivity

Description	α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand[1]. α,β-Methylene ATP dilithium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[2].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>P2X Receptor
References	[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1). [2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83

Description

α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand[1]. α,β-Methylene ATP dilithium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[2].

Related Catalog

Research Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>P2X Receptor

References

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83

Chemical & Physical Properties

Molecular Formula	C₁₁H₁₈Li₂N₅O₁₂P₃
Molecular Weight	519.09
Exact Mass	511.02500
PSA	302.16000
InChIKey	NVHVREPTGDOYIC-YCSZXMBFSA-M
SMILES	Nc1ncnc2c1ncn2C1OC(COP(=O)(O)CP(=O)(O)OP(=O)([O-])O)C(O)C1O.[Li+]
Storage condition	20°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	22-26-36
RIDADR	NONH for all modes of transport

Articles5

Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors.

Stem Cells Dev. 22(10) , 1506-21, (2013)

Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+...

Is there a basis for distinguishing two types of P2-purinoceptor?

Gen. Pharmacol. 16 , 433, (1985)

It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity of antagon...

The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate.

Br. J. Pharmacol. 112 , 282, (1994)

1. We have previously found that the P2x-purinoceptor agonist, alpha, beta-methylene adenosine 5'-triphosphate (alpha, beta-methylene ATP), depolarizes the rat cervical vagus nerve, measured with a 'g...

Synonyms

lithium,[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl-hydroxyphosphoryl] hydrogen phosphate

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