CAS 32507-66-7|Isorhapotogenin

Introduction：Basic information about CAS 32507-66-7|Isorhapotogenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Isorhapotogenin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Isorhapotogenin
CAS Number	32507-66-7	Molecular Weight	258.269
Density	1.3±0.1 g/cm3	Boiling Point	471.8±35.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄O₄	Melting Point	182 - 184ºC
MSDS	ChineseUSA	Flash Point	239.1±25.9 °C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	Isorhapontigenin
Synonym	More Synonyms

Isorhapotogenin BiologicalActivity

Description	Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/Immunology
References	[1]. Yeo SCM, et al. Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Br J Pharmacol. 2017 Jul;174(13):2043-2059. [2]. Liang Y, et al. SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers. Autophagy. 2016 Aug 2;12(8):1229-39. [3]. Jiang G, et al. Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis. Cancer Prev Res (Phila). 2016 Jul;9(7):567-80.

Description

Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/Immunology

References

[1]. Yeo SCM, et al. Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Br J Pharmacol. 2017 Jul;174(13):2043-2059.

[2]. Liang Y, et al. SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers. Autophagy. 2016 Aug 2;12(8):1229-39.

[3]. Jiang G, et al. Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis. Cancer Prev Res (Phila). 2016 Jul;9(7):567-80.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	471.8±35.0 °C at 760 mmHg
Melting Point	182 - 184ºC
Molecular Formula	C₁₅H₁₄O₄
Molecular Weight	258.269
Flash Point	239.1±25.9 °C
Exact Mass	258.089203
PSA	69.92000
LogP	2.90
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.722
InChIKey	ANNNBEZJTNCXHY-NSCUHMNNSA-N
SMILES	COc1cc(C=Cc2cc(O)cc(O)c2)ccc1O
Storage condition	room temp
Water Solubility	DMSO: soluble15mg/mL, clear

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	37/38-41-43-51
Safety Phrases	26-36/37/39
RIDADR	NONH for all modes of transport
HS Code	2909499000

Customs

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Synonyms

100mg

3',4',5'-trihydroxy-3-methoxystilbene

5-[(E)-2-(4-Hydroxy-3-methoxyphenyl)vinyl]benzene-1,3-diol

5-[(1E)-2-(4-Hydroxy-3-methoxyphenyl)ethenyl]-1,3-benzened

5-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]benzene-1,3-diol

5-[(E)-2-(4-Hydroxy-3-methoxyphenyl)vinyl]-1,3-benzenediol

(E)-3,4',5-Trihydroxy-3'-methoxystilbene

5-[(E)-2-(4-Hydroxy-3-methoxyphenyl)ethenyl]-1,3-benzenediol

1,3-Benzenediol, 5-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-

4,3',5'-trihydroxy-3-methoxystilbene

3,4',5-Trihydroxy-3'-methoxy-trans-stilbene

Isorhapontigenin

(E)-3'-Methoxystilbene-3,4',5-triol

(E)-3-Methoxy-stilbene-4,3',5'-triol

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