Introduction：Basic information about CAS 579-38-4|Diloxanide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Diloxanide |
|---|
| CAS Number | 579-38-4 | Molecular Weight | 234.07900 |
|---|
| Density | 1.439g/cm3 | Boiling Point | 356.2ºC at 760 mmHg |
|---|
| Molecular Formula | C9H9Cl2NO2 | Melting Point | 175° |
|---|
| MSDS | / | Flash Point | 169.2ºC |
|---|
Names
| Name | 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide |
|---|
| Synonym | More Synonyms |
|---|
Diloxanide BiologicalActivity
| Description | Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1]. |
|---|
| Related Catalog | Research Areas >>Infection |
|---|
| In Vivo | Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1]. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2]. |
|---|
| References | [1]. DB08792 [2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3. |
|---|
Chemical & Physical Properties
| Density | 1.439g/cm3 |
|---|
| Boiling Point | 356.2ºC at 760 mmHg |
|---|
| Melting Point | 175° |
|---|
| Molecular Formula | C9H9Cl2NO2 |
|---|
| Molecular Weight | 234.07900 |
|---|
| Flash Point | 169.2ºC |
|---|
| Exact Mass | 233.00100 |
|---|
| PSA | 40.54000 |
|---|
| LogP | 2.15870 |
|---|
| Index of Refraction | 1.615 |
|---|
| InChIKey | GZZZSOOGQLOEOB-UHFFFAOYSA-N |
|---|
| SMILES | CN(C(=O)C(Cl)Cl)c1ccc(O)cc1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AE1970600
- CHEMICAL NAME :
- Acetanilide, 2,2-dichloro-4'-hydroxy-N-methyl-
- CAS REGISTRY NUMBER :
- 579-38-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H9-Cl2-N-O2
- MOLECULAR WEIGHT :
- 234.09
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >12500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962
|
Synonyms
| Diloxanid |
| Amebamida |
| EINECS 209-439-4 |
| Diloxanide |
| RD 3803 |
| Acetamide,2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl |
| Diloxanidum [INN-Latin] |
| Entamide |
| Ame-boots |
| Diloxanida [INN-Spanish] |
