Introduction：Basic information about CAS 119625-78-4|Terlakiren, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Terlakiren |
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| CAS Number | 119625-78-4 | Molecular Weight | 620.80 |
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| Density | 1.205g/cm3 | Boiling Point | 908.3ºC at 760mmHg |
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| Molecular Formula | C31H48N4O7S | Melting Point | / |
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| MSDS | / | Flash Point | 503.1ºC |
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Names
| Name | propan-2-yl (2R,3S)-4-cyclohexyl-2-hydroxy-3-[[(2R)-3-methylsulfanyl-2-[[(2S)-2-(morpholine-4-carbonylamino)-3-phenylpropanoyl]amino]propanoyl]amino]butanoate |
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| Synonym | More Synonyms |
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Terlakiren BiologicalActivity
| Description | Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Renin |
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| References | [1]. Fouda H, et al. Quantitative analysis by high-performance liquid chromatography atmospheric pressure chemical ionization mass spectrometry: The determination of the renin inhibitor CP-80,794 in human serum. J Am Soc Mass Spectrom. 1991 Apr;2(2):164-7. |
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Chemical & Physical Properties
| Density | 1.205g/cm3 |
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| Boiling Point | 908.3ºC at 760mmHg |
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| Molecular Formula | C31H48N4O7S |
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| Molecular Weight | 620.80 |
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| Flash Point | 503.1ºC |
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| Exact Mass | 620.32400 |
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| PSA | 171.60000 |
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| LogP | 3.36560 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.554 |
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| InChIKey | UZQBKCWYZBHBOW-YIPNQBBMSA-N |
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| SMILES | CSCC(NC(=O)C(Cc1ccccc1)NC(=O)N1CCOCC1)C(=O)NC(CC1CCCCC1)C(O)C(=O)OC(C)C |
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Synonyms
| Terlakiren (USAN/INN) |
| N-(Morpholin-4-Ylcarbonyl)-L-Phenylalanyl-N-[(1r,2s)-1-(Cyclohexylmethyl)-2-Hydroxy-3-(1-Methylethoxy)-3-Oxopropyl]-S-Methyl-L-Cysteinamide |
| 2ZS |
| [R-(R*,S*)]-N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-[1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-(S)-methyl-L-cysteineamide |
| MOR-PHE-CYM-NOR |
