CAS 1784-03-8|TOS-ARG-OME.HCL
Introduction：Basic information about CAS 1784-03-8|TOS-ARG-OME.HCL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TOS-ARG-OME.HCL | ||
|---|---|---|---|
| CAS Number | 1784-03-8 | Molecular Weight | 378.875 |
| Density | / | Boiling Point | 544.1ºC at 760mmHg |
| Molecular Formula | C14H23ClN4O4S | Melting Point | 145-147(lit.) |
| MSDS | USA | Flash Point | 282.9ºC |
Names
| Name | methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate,hydrochloride |
|---|---|
| Synonym | More Synonyms |
TOS-ARG-OME.HCL BiologicalActivity
| Description | TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>APCResearch Areas >>Cancer |
| Target | APC [1]. |
| In Vitro | TAME shows inhibitory effect on APC activation when added to mitotic Xenopus extract. TAME (1-200 μM) inhibits Cdc20 association with mitotic APC and also inhibits Cdh1 association with interphase APC. TAME significantly inhibits crosslinking of the IR peptide to Cdc27 and Cdc16 but only slightly reduces crosslinking to Cdc23 and Apc7 at 20 µM; TAME strongly inhibits crosslinking to all APC subunits at 200 µM. TAME also inhibits binding of wild type Cdc20 to the APC, but not binding of a ΔIR mutant[1]. TAME (200 μM) induces Cdc20 dissociation from the APC in mitotic Xenopus extract calls for APC-dependent ubiquitination. TAME induces Cdc20 dissociation from the APC by promoting Cdc20 ubiquitination, but the dissociation can be suppresses by Cyclin B1. TAME terminates cyclin B1 ubiquitination prematurely[2]. TAME interacts with ATP by β and γ phosphate and the adenine ring of ATP. TAME in combination with the Mg(II) ion accelerates the ATP hydrolysis process[3]. |
| References | [1]. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [2]. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. [3]. Ma Y, et al. Differential effects of Mg(ii) and N(alpha)-4-tosyl-l-arginine methyl ester hydrochloride on the recognition and catalysis in ATP hydrolysis. Dalton Trans. 2008 Feb 28;(8):1081-6. |
Chemical & Physical Properties
| Boiling Point | 544.1ºC at 760mmHg |
|---|---|
| Melting Point | 145-147(lit.) |
| Molecular Formula | C14H23ClN4O4S |
| Molecular Weight | 378.875 |
| Flash Point | 282.9ºC |
| Exact Mass | 378.112854 |
| PSA | 142.75000 |
| LogP | 3.54280 |
| Vapour Pressure | 6.73E-12mmHg at 25°C |
| Index of Refraction | -14 ° (C=4, H2O) |
| InChIKey | JIQFFACVQXXHMY-YDALLXLXSA-N |
| SMILES | COC(=O)C(CCCN=C(N)N)NS(=O)(=O)c1ccc(C)cc1.Cl |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles5
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| Rabbit plasminogen and plasmin isozymes. Meth. Enzymol. 45 , 273, (1976) | |
| A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. Can. J. Biochem. Physiol. 37 , 1393, (1959) |
Synonyms
| Nalpha-4-Tosyl-L-arginine methyl ester hydrochloride |
| Na-p-Tosyl-L-arginine methyl ester hydrochloride |
| (S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate hydrochloride |
| Nα-p-Toluenesulfonyl-L-arginine Methyl Ester Hydrochloride |
| N-4-Tosyl-L-arginine methyl ester hydrochloride |
| Tos-Arg-OMe.HCl |
| Tos-Arg-Ome·Hcl |
| EINECS 217-235-1 |
| TAME hydrochloride |
| Imino{[(4S)-5-methoxy-4-{[(4-methylphenyl)sulfonyl]amino}-5-oxopentyl]amino}methanaminium chloride |
| MFCD00012578 |
| L-Ornithine, N-(diaminomethylene)-N-[(4-methylphenyl)sulfonyl]-, methyl ester, hydrochloride (1:1) |
| Nα-p-Tosyl-L-arginine methyl ester hydrochloride |
| Methyl N2-((p-tolyl)sulphonyl)-L-argininate monohydrochloride |
| Nalpha-Tosyl-L-arginine Methyl Ester Hydrochloride |
| TOS-ARG-OME HCL |
| Methyl N-(diaminomethylene)-N-[(4-methylphenyl)sulfonyl]-L-ornithinate hydrochloride (1:1) |
| Nα-Tosyl-L-arginine Methyl Ester Hydrochloride |
| Nalpha-p-Toluenesulfonyl-L-Arginine Methyl Ester Hydrochloride |
