Introduction：Basic information about CAS 480-39-7|Pinocembrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pinocembrin |
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| CAS Number | 480-39-7 | Molecular Weight | 256.25 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 511.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C15H12O4 | Melting Point | / |
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| MSDS | USA | Flash Point | 199.3±23.6 °C |
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Names
| Name | pinocembrin |
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| Synonym | More Synonyms |
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Pinocembrin BiologicalActivity
| Description | Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Pinocembrin (5, 10, 25, 50, 100 or 200 µM, 24 hours) significantly reduces cell viability of RBL-2H3 cells[1]. Pinocembrin (25 or 50 µM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α[1]. Cell Viability Assay[1] Cell Line: RBL-2H3 cells Concentration: 5, 10, 25, 50, 100 or 200 µM Incubation Time: 24 hours Result: Decreased cell viability by ∼50% at ≥ 100 µM. Showed 75% cell viability at lower concentrations. |
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| References | [1]. Hanieh H, et al. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. Eur J Pharmacol. 2017 Nov 5;814:178-186. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 511.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C15H12O4 |
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| Molecular Weight | 256.25 |
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| Flash Point | 199.3±23.6 °C |
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| Exact Mass | 256.073547 |
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| PSA | 66.76000 |
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| LogP | 3.93 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.662 |
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| InChIKey | URFCJEUYXNAHFI-ZDUSSCGKSA-N |
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| SMILES | O=C1CC(c2ccccc2)Oc2cc(O)cc(O)c21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NQ5233332
- CHEMICAL NAME :
- 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-
- CAS REGISTRY NUMBER :
- 480-39-7
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DARUEE Dokl Akad Nauk resp. Uzb. Volume(issue)/page/year: (9-10),55,1995
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Safety Information
Synonyms
| Galangin flavanone |
| (2S)-5,7-Dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one |
| Pinocembrin |
| (2S)-pinocembrin |
| Dihydrochrysin |
| (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one |
| 5,7-Dihydroxyflavanone |
| 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- |
| (2S)-5,7-dihydroxy-2-phenylchroman-4-one |
| 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-(-)- |
