Introduction：Basic information about CAS 322-35-0|2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide |
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| CAS Number | 322-35-0 | Molecular Weight | 257.24300 |
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| Density | 1.541 g/cm3 | Boiling Point | 574.2ºC at 760 mmHg |
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| Molecular Formula | C10H15N3O5 | Melting Point | / |
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| MSDS | / | Flash Point | 301ºC |
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Names
| Name | benserazide |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| References | [1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151. |
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Chemical & Physical Properties
| Density | 1.541 g/cm3 |
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| Boiling Point | 574.2ºC at 760 mmHg |
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| Molecular Formula | C10H15N3O5 |
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| Molecular Weight | 257.24300 |
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| Flash Point | 301ºC |
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| Exact Mass | 257.10100 |
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| PSA | 148.07000 |
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| Index of Refraction | 1.678 |
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| InChIKey | BNQDCRGUHNALGH-UHFFFAOYSA-N |
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| SMILES | NC(CO)C(=O)NNCc1ccc(O)c(O)c1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VT9632200
- CHEMICAL NAME :
- Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-
- CAS REGISTRY NUMBER :
- 322-35-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C10-H15-N3-O5
- MOLECULAR WEIGHT :
- 257.28
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23400 mg/kg/90D-C
- TOXIC EFFECTS :
- Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2880 mg/kg
- SEX/DURATION :
- female 90 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26 |
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| HS Code | 2928000090 |
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Customs
| HS Code | 2928000090 |
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| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Synonyms
| bensarazide |
| Benseraszide |
| Ro 4-4602 |
| Benserazida |
| DL-Seryltrihydroxybenzylhydrazine |
| MFCD00242633 |
| 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide |
| Serazide |
| Benserazidum |
