CAS 74285-86-2|Triptophenolide

Introduction：Basic information about CAS 74285-86-2|Triptophenolide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Triptophenolide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Triptophenolide
CAS Number	74285-86-2	Molecular Weight	312.403
Density	1.2±0.1 g/cm3	Boiling Point	490.0±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₄O₃	Melting Point	232-233ºC
MSDS	/	Flash Point	202.4±21.5 °C

Names

Name	6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e][2]benzofuran-1-one
Synonym	More Synonyms

Triptophenolide BiologicalActivity

Description	Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo:
Related Catalog	Signaling Pathways >>Others >>Androgen ReceptorResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides
References	[1]. XU bin, et al. Study on polarographic catalytic wave of triptophenolide. Chinese Journal of Analysis Laboratory, 2005-04 [2]. Yang Jun, et al. Studies on Antiinflammatory and Immune Effects of Triptophenolide. Chinese Traditional and Herbal Drugs, 1995-01

Description

Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo:

Related Catalog

Signaling Pathways >>Others >>Androgen ReceptorResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides

References

[1]. XU bin, et al. Study on polarographic catalytic wave of triptophenolide. Chinese Journal of Analysis Laboratory, 2005-04

[2]. Yang Jun, et al. Studies on Antiinflammatory and Immune Effects of Triptophenolide. Chinese Traditional and Herbal Drugs, 1995-01

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	490.0±45.0 °C at 760 mmHg
Melting Point	232-233ºC
Molecular Formula	C₂₀H₂₄O₃
Molecular Weight	312.403
Flash Point	202.4±21.5 °C
Exact Mass	312.172546
PSA	46.53000
LogP	3.92
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.603
InChIKey	KPXIBWGPZSPABK-FXAWDEMLSA-N
SMILES	CC(C)c1ccc2c(c1O)CCC1C3=C(CCC21C)C(=O)OC3
Storage condition	-20°C

Safety Information

Risk Phrases	R20/21/22
Safety Phrases	S36/37

Synonyms

Triptophenolide

Phenanthro[1,2-c]furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR,9bS)-

6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one

(3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one

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