CAS 37067-30-4|4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide
| Common Name | 4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide | ||
|---|---|---|---|
| CAS Number | 37067-30-4 | Molecular Weight | 379.361 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 732.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H21NO8 | Melting Point | 208-210 °C |
| MSDS | ChineseUSA | Flash Point | 396.6±32.9 °C |
Names
| Name | 4-METHYLUMBELLIFERYL-N-ACETYL-β-D-GLUCOSAMINIDE |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | The enzyme functionality is assessed by its ability remove terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside[1]. |
| References | [1]. Li J, et, al. Identification of a specific inhibitor of nOGA - a caspase-3 cleaved O-GlcNAcase variant during apoptosis. Biochemistry (Mosc). 2012 Feb;77(2):194-200. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 732.2±60.0 °C at 760 mmHg |
| Melting Point | 208-210 °C |
| Molecular Formula | C18H21NO8 |
| Molecular Weight | 379.361 |
| Flash Point | 396.6±32.9 °C |
| Exact Mass | 379.126709 |
| PSA | 138.46000 |
| LogP | 0.34 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.632 |
| InChIKey | QCTHLCFVVACBSA-JVNHZCFISA-N |
| SMILES | CC(=O)NC1C(Oc2ccc3c(C)cc(=O)oc3c2)OC(CO)C(O)C1O |
| Storage condition | −20°C |
| Stability | Light Sensitive - Protect from Light |
| Water Solubility | DMF: 20 mg/mL, clear, colorless |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles27
More Articles| Tay-Sachs disease heterozygote detection: use of a centrifugal analyser for automation of hexosaminidase assays with two different artificial substrates. J. Med. Genet. 28(2) , 101-9, (1991) An assay for measuring hexosaminidase A in serum and leucocytes is described in which a centrifugal analyser is used for automation of the enzyme assays after manual heat inactivation. The assay was u... | |
| TNFalpha-induced macrophage death via caspase-dependent and independent pathways. Apoptosis 14(3) , 320-32, (2009) Macrophages are the principal source of TNFalpha, yet they are highly resistant to TNFalpha-mediated cell death. Previously, employing in vitro differentiated human macrophages, we showed that followi... | |
| A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate. Electrophoresis 15(5) , 662-5, (1994) A method for the detection of N-acetylglucosaminidase (GlcNAcase) activity has been developed by using 4-methyl-umbelliferyl-N-acetyl-D-glucosaminide (4-MU-GlcNAc) as substrate in crossed immunoelectr... |
Synonyms
| 4-Methyl-2-oxo-2H-chromen-7-yl 2-acetamido-2-deoxy-β-D-glucopyranoside |
| 4-Methylumbelliferyl 2-Acetamido-2-deoxy-β-D-glucopyranoside |
| GLCNAC1-B-4MU |
| MFCD00065481 |
| 4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide |
| 4-Methylumbelliferyl-N-acetyl-β-D-glucosaminide |
| 7-((2-Acetamido-2-deoxy-β-D-glucopyranosyl)oxy)-4-methyl-2H-1-benzopyran-2-one |
| EINECS 253-333-0 |
| Methylumbelliferyl-N-acetyl-b-D-glucosaminide |
| 2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-4-methyl- |
| T66 BOVJ E1 IO- BT6OTJ CMV1 DQ EQ F1Q &&β-D-Gluco Form |
