Introduction：Basic information about CAS 486-12-4|triprolidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | triprolidine |
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| CAS Number | 486-12-4 | Molecular Weight | 278.39100 |
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| Density | 1.061 g/cm3 | Boiling Point | 435.4ºC at 760 mmHg |
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| Molecular Formula | C19H22N2 | Melting Point | 126-130°C |
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| MSDS | / | Flash Point | 217.1ºC |
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Names
| Name | triprolidine |
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| Synonym | More Synonyms |
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triprolidine BiologicalActivity
| Description | Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>InfectionSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| In Vitro | Triprolidine (maturing human dendritic cells) can antagonist histamine H1 and decreases the expression of CD45[1]. |
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| In Vivo | Triprolidine (292.81-1467.20 μg/kg; i.p.; Male Sprague-Dawley rat) produces a dose-dependent effect of spinal motor and sensory block in rats[2]. Animal Model: Male Sprague-Dawley rat (300-350 g)[2] Dosage: 292.81, 488.02, 733.60, 1098.83 and 1467.20 μg/kg Administration: Intrathecal injection Result: Elicited spinal block in a dose-dependent. |
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| References | [1]. Szeberényi JB, et, al. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol Lett. 2001 Apr 2;76(3):175-82. [2]. Tzeng JI, et, al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661. [3]. Deal DL, Chandrasurin P, Shockcor J, Minick DJ, Findlay JW, McNulty MJ. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. 1992 Nov-Dec;20(6):920-7. |
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Chemical & Physical Properties
| Density | 1.061 g/cm3 |
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| Boiling Point | 435.4ºC at 760 mmHg |
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| Melting Point | 126-130°C |
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| Molecular Formula | C19H22N2 |
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| Molecular Weight | 278.39100 |
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| Flash Point | 217.1ºC |
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| Exact Mass | 278.17800 |
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| PSA | 16.13000 |
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| LogP | 3.85540 |
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| Vapour Pressure | 6.16E-09mmHg at 25°C |
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| InChIKey | CBEQULMOCCWAQT-WOJGMQOQSA-N |
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| SMILES | Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UT5812000
- CHEMICAL NAME :
- Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)- , (E)-
- CAS REGISTRY NUMBER :
- 486-12-4
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H22-N2
- MOLECULAR WEIGHT :
- 278.43
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 143 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - alteration of operant conditioning Behavioral - changes in psychophysiological tests
- REFERENCE :
- EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970- Volume(issue)/page/year: 47,331,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 mg/kg/90D-C
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,96,1985
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Safety Information
Synonyms
| MFCD00038040 |
| (e)-pyridin |
| Triprolidin |
| (E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine |
| (E)-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene |
| trans-2-[3-(1-Pyrrolidinyl)-1-p-tolypropenyl]pyridine |
| trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene |
| trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine |
| EINECS 207-627-0 |
| Triprolidine |
| Tripyrolidine |
| 1t-[2]Pyridyl-3-pyrrolidino-1c-p-tolyl-propen |
| (E)-1-(2-pyridyl)-3-pyrrolidin-1-yl-1-p-tolylpropene |
| 1t-[2]pyridyl-3-pyrrolidino-1c-p-tolyl-propene |
| (E)-2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine |
