CAS 565-20-8|N-acetyl Dapsone

Introduction：Basic information about CAS 565-20-8|N-acetyl Dapsone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. N-acetyl Dapsone BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	N-acetyl Dapsone
CAS Number	565-20-8	Molecular Weight	290.34
Density	1.362g/cm3	Boiling Point	589.5ºC at 760mmHg
Molecular Formula	C₁₄H₁₄N₂O₃S	Melting Point	238-240ºC
MSDS	/	Flash Point	310.3ºC

Names

Name	N-Acetyl Dapsone
Synonym	More Synonyms

N-acetyl Dapsone BiologicalActivity

Description	N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5. [2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

Description

N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5.

[2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

Chemical & Physical Properties

Density	1.362g/cm3
Boiling Point	589.5ºC at 760mmHg
Melting Point	238-240ºC
Molecular Formula	C₁₄H₁₄N₂O₃S
Molecular Weight	290.34
Flash Point	310.3ºC
Exact Mass	290.07300
PSA	97.64000
LogP	3.79500
Index of Refraction	1.641
InChIKey	WDOCBIHNYYQINH-UHFFFAOYSA-N
SMILES	CC(=O)Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE7020000

CHEMICAL NAME :: Acetanilide, 4'-sulfanilyl-

CAS REGISTRY NUMBER :: 565-20-8

BEILSTEIN REFERENCE NO. :: 2746651

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H14-N2-O3-S

MOLECULAR WEIGHT :: 290.36

WISWESSER LINE NOTATION :: ZR DSWR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 6,251,1951

Safety Information

Hazard Codes	Xi
Risk Phrases	37/38-41-43
Safety Phrases	26-36/37/39
WGK Germany	2
RTECS	AE7020000

Synonyms

N-[4-(4-aminophenyl)sulfonylphenyl]acetamide

Mono-N-acetyl-4-4'-sulfonylbisbenzeneamine

Recommended......