Introduction：Basic information about CAS 6029-87-4|Fulvine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fulvine |
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| CAS Number | 6029-87-4 | Molecular Weight | 309.35800 |
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| Density | 1.27g/cm3 | Boiling Point | 552.8ºC at 760 mmHg |
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| Molecular Formula | C16H23NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 288.1ºC |
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Names
| Name | 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione,4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-,(3R,4S,5S,13aR,13bR)- (9CI) |
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| Synonym | More Synonyms |
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Fulvine BiologicalActivity
| Description | Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| References | [1]. J M Kay, et al.Fulvine and the pulmonary circulation. Thorax |
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Chemical & Physical Properties
| Density | 1.27g/cm3 |
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| Boiling Point | 552.8ºC at 760 mmHg |
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| Molecular Formula | C16H23NO5 |
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| Molecular Weight | 309.35800 |
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| Flash Point | 288.1ºC |
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| Exact Mass | 309.15800 |
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| PSA | 76.07000 |
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| LogP | 0.43040 |
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| Index of Refraction | 1.563 |
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| InChIKey | PSUFRPOAICRSTC-ULRTWBKGSA-N |
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| SMILES | CC1C(=O)OCC2=CCN3CCC(OC(=O)C(C)C1(C)O)C23 |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RC1300000
- CHEMICAL NAME :
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-13-hydroxy-, (12-xi,13-xi)-
- CAS REGISTRY NUMBER :
- 6029-87-4
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C16-H23-N-O5
- MOLECULAR WEIGHT :
- 309.40
- WISWESSER LINE NOTATION :
- T55-11- 1A P EN IOV NVO BUTJ K1 LQ L1 M1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 9-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 9-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 9-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 9-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA - TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- JOGNAU Journal of Genetics. (Belghoria, India) V.1-63, 1910-77. Discontinued. Volume(issue)/page/year: 59,273,1966
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Safety Information
Synonyms
| fulvine |
| 13-Epicrispatine |
| Fulvine (8ci) |
