Introduction：Basic information about CAS 1024-99-3|5-Iodouridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Iodouridine |
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| CAS Number | 1024-99-3 | Molecular Weight | 370.10 |
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| Density | 2.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H11IN2O6 | Melting Point | 205-207ºC (dec.)(lit.) |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 5-Iodouridine |
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| Synonym | More Synonyms |
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5-Iodouridine BiologicalActivity
| Description | 5-Iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Density | 2.3±0.1 g/cm3 |
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| Melting Point | 205-207ºC (dec.)(lit.) |
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| Molecular Formula | C9H11IN2O6 |
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| Molecular Weight | 370.10 |
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| Exact Mass | 369.966156 |
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| PSA | 124.78000 |
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| LogP | -0.43 |
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| Index of Refraction | 1.748 |
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| Storage condition | 2-8°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 22-24/25-36/37/39-27-26 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| Loss of Foxm1 Results in Reduced Somatotrope Cell Number during Mouse Embryogenesis. PLoS ONE 10 , e0128942, (2015) FOXM1, a member of the forkhead box transcription factor family, plays a key role in cell cycling progression by regulating the expression of critical G1/S and G2/M phase transition genes. In vivo stu... | |
| Synthesis of uridine phosphoramidite analogs: reagents for site-specific incorporation of photoreactive sites into RNA sequences. Bioconjug. Chem. 5(6) , 508-12, (1994) The synthesis of three new photoactive RNA phosphoramidites, 5-bromouridine, 5-iodouridine, and O4-triazolouridine, is reported. The 5' OH of bromouridine and iodouridine were protected as dimethoxytr... | |
| Phosphine containing oligonucleotides for the development of metallodeoxyribozymes. Chem. Commun. (Camb.) (15) , 1556-8, (2007) Novel transition metal catalysts based on oligonucleotides can be easily obtained by functionalization of 5-iodouridine with phosphine ligands, resulting in good asymmetric induction in palladium cata... | |
Synonyms
| 5-Iodouridine |
| 5-Iod-uridin |
| 5-Iodoruidine |
| 2,4-Dihydroxy-5-iodo-1-β-D-ribofuranosylpyrimidine |
| Uridine, 5-iodo- |
| 5-iodo-uridine |
| EINECS 213-833-1 |
| 5-Jod-uridin |
| 5-Iodo-D-uridine |
| MFCD00006532 |
