CAS 100234-59-1|Picrasidine I

Introduction：Basic information about CAS 100234-59-1|Picrasidine I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Picrasidine I BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Picrasidine I
CAS Number	100234-59-1	Molecular Weight	240.257
Density	1.4±0.1 g/cm3	Boiling Point	528.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂N₂O₂	Melting Point	/
MSDS	/	Flash Point	273.3±28.7 °C

Names

Name	4-Methoxy-1-vinyl-9H-β-carbolin-8-ol
Synonym	More Synonyms

Picrasidine I BiologicalActivity

Description	Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/Immunology
References	[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103. [2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435.

Description

Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell Apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/Immunology

References

[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103.

[2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	528.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂N₂O₂
Molecular Weight	240.257
Flash Point	273.3±28.7 °C
Exact Mass	240.089874
PSA	58.14000
LogP	3.05
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.772
InChIKey	JOHWQLSNGRWJRK-UHFFFAOYSA-N
SMILES	C=Cc1ncc(OC)c2c1[nH]c1c(O)cccc12

Safety Information

Hazard Codes	Xi

Synonyms

4-Methoxy-1-vinyl-9H-Beta-carbolin-8-ol

Picrasidine I

4-ethyl-quinolin-8-ol

8-Quinolinol,4-ethyl

9H-Pyrido[3,4-b]indol-8-ol, 1-ethenyl-4-methoxy-

8-Hydroxy-4-ethyl-chinolin

4-Methoxy-1-vinyl-9H-β-carbolin-8-ol

8-hydroxydehydrocrenatine

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