Introduction：Basic information about CAS 22136-74-9|Podocarpusflavone A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Podocarpusflavone A |
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| CAS Number | 22136-74-9 | Molecular Weight | 552.484 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 879.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C31H20O10 | Melting Point | / |
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| MSDS | / | Flash Point | 295.2±27.8 °C |
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Names
| Name | 8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-d ihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one |
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| Synonym | More Synonyms |
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Podocarpusflavone A BiologicalActivity
| Description | Podocarpusflavone A is a DNA topoisomerase I inhibitor, have moderated anti-proliferative activity induce cell apoptosis in MCF-7, is developing anti-tumor drugstarget: DNA topoisomerase IIn vitro: podocarpusflavone-A show significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 4.56-16.24 μg/mL) and induce cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. PF (40 ug/mL, 24 hr) significantly induced about 10 folds of cell deaths and growth arrest in S-phase than the control group. |
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| Related Catalog | Research Areas >>CancerNatural Products >>Flavonoids |
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| Target | Topoisomerase I:119.425 μM (IC50) |
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| References | [1]. Pen-Ho Yeh et al. Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaiiJ Tradit Complement Med. 2012 Jul;2(3):220-6. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 879.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C31H20O10 |
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| Molecular Weight | 552.484 |
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| Flash Point | 295.2±27.8 °C |
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| Exact Mass | 552.105652 |
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| PSA | 170.80000 |
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| LogP | 4.15 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.750 |
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| InChIKey | RBTRUVNXLDXHBJ-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cc(=O)c3c(O)cc(O)c(-c4cc(-c5cc(=O)c6c(O)cc(O)cc6o5)ccc4O)c3o2)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one |
| Podocarpusflavone A |
| 4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)- |
| 9-Methylacridin |
| 4-Methylakridin |
| 4'''-methylamentoflavone |
| 4-Methylacridin |
| 1-Methylacridin |
| ACRIDINE,4-METHYL |
| 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)- |
| 4-methyl-acridine |
