CAS 483-66-9|Sphondin

Introduction：Basic information about CAS 483-66-9|Sphondin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sphondin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Sphondin
CAS Number	483-66-9	Molecular Weight	216.189
Density	1.4±0.1 g/cm3	Boiling Point	413.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₈O₄	Melting Point	/
MSDS	/	Flash Point	203.6±28.7 °C

Names

Name	6-methoxyfuro[2,3-h]chromen-2-one
Synonym	More Synonyms

Sphondin BiologicalActivity

Description	Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX
Target	COX-2
In Vitro	Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release[1].
References	[1]. Ling Ling Yang, et al. Effects of Sphondin, Isolated From Heracleum Laciniatum, on IL-1beta-induced cyclooxygenase-2 Expression in Human Pulmonary Epithelial Cells. Life Sci. 2002 Nov 29;72(2):199-213.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	413.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₈O₄
Molecular Weight	216.189
Flash Point	203.6±28.7 °C
Exact Mass	216.042252
PSA	52.58000
LogP	1.83
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.635
InChIKey	DLCJNIBLOSKIQW-UHFFFAOYSA-N
SMILES	COc1cc2ccc(=O)oc2c2ccoc12

Safety Information

Hazard Codes	Xi

Synonyms

6-Methoxy-2H-furo[2,3-h]chromen-2-one

Sfondin

6-Methoxyfuro[2,3-h]chromen-2-one

2H-Furo[2,3-h]-1-benzopyran-2-one, 6-methoxy-

6-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one

Sphondin

6-Methoxy-furano-<2',3'-7,8>cumarin,Sphondin

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