Introduction：Basic information about CAS 934660-94-3|Cobimetinib (R-enantiomer), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cobimetinib (R-enantiomer) |
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| CAS Number | 934660-94-3 | Molecular Weight | 531.31000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H21F3IN3O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2R)-piperidin-2-yl]azetidin-1-yl]methanone |
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| Synonym | More Synonyms |
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Cobimetinib (R-enantiomer) BiologicalActivity
| Description | Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. |
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| Related Catalog | Research Areas >>Cancer |
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| References | [1]. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9. |
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Chemical & Physical Properties
| Molecular Formula | C21H21F3IN3O2 |
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| Molecular Weight | 531.31000 |
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| Exact Mass | 531.06300 |
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| PSA | 64.60000 |
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| LogP | 4.12080 |
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| InChIKey | BSMCAPRUBJMWDF-QGZVFWFLSA-N |
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| SMILES | O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)(C2CCCCN2)C1 |
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Synonyms
| 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-[(2R)-piperidin-2-yl]azetidin-3-ol |
| Cobimetinib (R-enantiomer) |
| (R)-XL518 |
| GDC-0973 R-enantiomer |
| CS-1022 |
