Introduction：Basic information about CAS 501364-82-5|INO-1001, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | INO-1001 |
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| CAS Number | 501364-82-5 | Molecular Weight | 439.52700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H25N3O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-[3-(4-Morpholinyl)propyl]-5-oxo-6,11-dihydro-5H-indeno[1,2-c]is oquinoline-9-sulfonamide |
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| Synonym | More Synonyms |
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INO-1001 BiologicalActivity
| Description | INO-1001 is a potent and selective Poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 0.05-1 μM. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| Target | PARP:0.05-1 μM (IC50) |
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| References | [1]. Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60. [2]. Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13. |
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Chemical & Physical Properties
| Molecular Formula | C23H25N3O4S |
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| Molecular Weight | 439.52700 |
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| Exact Mass | 439.15700 |
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| PSA | 100.14000 |
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| LogP | 3.92180 |
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| InChIKey | LTZVLHHIAUKGBP-UHFFFAOYSA-N |
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| SMILES | O=c1[nH]c2c(c3ccccc13)Cc1cc(S(=O)(=O)NCCCN3CCOCC3)ccc1-2 |
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Synonyms
| 9-[N-(3-[morpholin-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno[1,2-c]isoquinoline |
| inotec indeno[1,2c]isoquinoline |
| 9H-Xanthene,9-[bis(4-methoxyphenyl)methylene] |
| 9-[N-(3-[morpholino-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno-[1,2-c]isoquinoline |
| 9-<Bis-(4-methoxy-phenyl)-methylen>-xanthen |
