Introduction：Basic information about CAS 245765-41-7|Ozenoxacin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ozenoxacin |
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| CAS Number | 245765-41-7 | Molecular Weight | 363.410 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 573.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H21N3O3 | Melting Point | / |
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| MSDS | / | Flash Point | 300.7±30.1 °C |
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Names
| Name | 1-cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)pyridin-3-yl]-4-oxoquinoline-3-carboxylic acid |
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| Synonym | More Synonyms |
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Ozenoxacin BiologicalActivity
| Description | Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
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| Target | Bacterial[1] |
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| In Vitro | Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positive microorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains of MRSA, MSSA, MSSE, and MRSE with 2, 3, or 4 mutations in the gyrA and grlA (parC) genes[1]. Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of >10−10 and 5.3 × 10−10, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin[2]. |
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| References | [1]. López Y, et al. In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria. Antimicrob Agents Chemother. 2013 Dec;57(12):6389-92. [2]. López Y, et al. In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci. J Antimicrob Chemother. 2015 Jan;70(1):57-61 |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 573.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H21N3O3 |
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| Molecular Weight | 363.410 |
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| Flash Point | 300.7±30.1 °C |
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| Exact Mass | 363.158295 |
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| PSA | 87.45000 |
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| LogP | 3.41 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.694 |
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| InChIKey | XPIJWUTXQAGSLK-UHFFFAOYSA-N |
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| SMILES | CNc1ncc(-c2ccc3c(=O)c(C(=O)O)cn(C4CC4)c3c2C)cc1C |
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| Storage condition | 2-8℃ |
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Synonyms
| T 3912 |
| UNII-V0LH498RFO |
| 1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid |
| Ozenoxacin (JAN/INN) |
| 3-Quinolinecarboxylic acid, 1-cyclopropyl-1,4-dihydro-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo- |
| ozenoxacin |
