CAS 760173-05-5|Etamicastat

Introduction：Basic information about CAS 760173-05-5|Etamicastat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Etamicastat BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Etamicastat
CAS Number	760173-05-5	Molecular Weight	311.35
Density	1.44	Boiling Point	435.308ºC at 760 mmHg
Molecular Formula	C₁₄H₁₅F₂N₃OS	Melting Point	/
MSDS	/	Flash Point	217.067ºC

Names

Name	4-(2-aminoethyl)-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione
Synonym	More Synonyms

Etamicastat BiologicalActivity

Description	Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1].
Related Catalog	Research Areas >>Cardiovascular Disease
Target	Dopamine-β-hydroxylase (DβH)[1]
In Vivo	Upon intraperitoneal administration to NMRi mice, Etamicastat (100 mg/ kg) leads to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control)[2]. Etamicastat (50 mg/kg) is rapidly absorbed into the systemic circulation reaching a maximum concentration at 4 h post-administration, representing 29% of total Etamicastat and quantified metabolites, using AUC0-t as a measure of systemic exposure[2].
References	[1]. Vaz-da-Silva M, et al. Effect of food on the pharmacokinetic profile of Etamicastat (BIA 5-453). Drugs R D. 2011;11(2):127-36. [2]. Loureiro AI, et al. Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94.

Chemical & Physical Properties

Density	1.44
Boiling Point	435.308ºC at 760 mmHg
Molecular Formula	C₁₄H₁₅F₂N₃OS
Molecular Weight	311.35
Flash Point	217.067ºC
Exact Mass	311.09000
PSA	91.87000
LogP	2.82770
InChIKey	CWWWTTYMUOYSQA-LLVKDONJSA-N
SMILES	NCCc1c[nH]c(=S)n1C1COc2c(F)cc(F)cc2C1

Synonyms

UNII-9X96V6DBU4

Etamitat

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