Introduction：Basic information about CAS 898563-00-3|TP-10, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TP-10 |
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| CAS Number | 898563-00-3 | Molecular Weight | 460.45000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H19F3N4O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-({4-[4-(4-Pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]p henoxy}methyl)quinoline |
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| Synonym | More Synonyms |
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TP-10 BiologicalActivity
| Description | TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.IC50 value: 0.8 nM [1]Target: PDE10ATP-10 has extremely potent PDE10A inhibitory activity and highselectivity against other PDEs, and be active in the mouse behavioral model for positive symptoms. TP-10 demonstrats good in vitro and in vivo activity, the intrinsic clearance (CLint) of these compounds in mouse liver microsomes (MLM) was extremely high in assay (CLint>1000 mL/min/kg). [1] |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Cardiovascular Disease |
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| References | [1]. Hamaguchi W, et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem Pharm Bull (Tokyo). 2014;62(12):1200-1213. [2]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem |
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Chemical & Physical Properties
| Molecular Formula | C26H19F3N4O |
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| Molecular Weight | 460.45000 |
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| Exact Mass | 460.15100 |
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| PSA | 52.83000 |
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| LogP | 6.30160 |
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| InChIKey | NOIXNOMHHWGUTG-UHFFFAOYSA-N |
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| SMILES | FC(F)(F)Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1 |
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| Storage condition | 2-8℃ |
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Synonyms
