CAS 230615-23-3|Varenicline (Hydrochloride)

Introduction：Basic information about CAS 230615-23-3|Varenicline (Hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Varenicline (Hydrochloride) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Varenicline (Hydrochloride)
CAS Number	230615-23-3	Molecular Weight	247.723
Density	/	Boiling Point	/
Molecular Formula	C₁₃H₁₄ClN₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
Synonym	More Synonyms

Varenicline (Hydrochloride) BiologicalActivity

Description	Varenicline Hcl(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease
References	[1]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers. Journal of Clinical Pharmacology (2011), 51(4), 527-537. [2]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2. [3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125. [4]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34.

Description

Varenicline Hcl(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking.

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease

References

[1]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers. Journal of Clinical Pharmacology (2011), 51(4), 527-537.

[2]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2.

[3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125.

[4]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34.

Chemical & Physical Properties

Molecular Formula	C₁₃H₁₄ClN₃
Molecular Weight	247.723
Exact Mass	247.087631
PSA	37.81000
LogP	2.93470
InChIKey	ZUCZFANFKYSVKF-UHFFFAOYSA-N
SMILES	Cl.c1cnc2cc3c(cc2n1)C1CNCC3C1
Storage condition	2-8℃

Synonyms

5,8,14-Triazatetracyclo[10.3.1.0.0]hexadeca-2,4,6,8,10-pentaene hydrochloride (1:1)

5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene hydrochloride

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine,7,8,9,10-tetrahydro-,hydrochloride (1:1)

Varenicline (Hydrochloride)

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, hydrochloride (1:1)

Chantix hydrochloride

6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride

6,10-Methano-6H-azepino[4,5-g]quinoxaline, 7,8,9,10-tetrahydro-, hydrochloride (1:1)

7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride

6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine,6,7,8,9-tetrahydro-,monohydrochloride (Varenicline Hcl)

ChaMpix hydrochloride

Recommended......