Introduction：Basic information about CAS 10448-84-7|Nitromifene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nitromifene |
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| CAS Number | 10448-84-7 | Molecular Weight | 444.52200 |
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| Density | 1.183g/cm3 | Boiling Point | 576.7ºC at 760mmHg |
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| Molecular Formula | C27H28N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 302.6ºC |
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Names
| Name | 1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine |
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| Synonym | More Synonyms |
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Nitromifene BiologicalActivity
| Description | Nitromifene is an antagonist of estrogen receptor (ER). |
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| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer |
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| Target | ER[1] |
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| In Vitro | Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1]. |
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| Cell Assay | MCF 7 cells are used in this study. The experiment is carried out in 6-well cluster plates. To each well is added 5 mL of a suspension of 2×105 cells in log phase growth. Medium is changed after 48 h and after 96 h, medium is replaced with 5 mL of serum-free medium containing 2 nM of the radioligand. Nitromifene is dissolved in DMSO (5 μL) to give final concentrations of 0, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM. Nonspecific binding is determined in incubations to which the radioinert counterpart of the radioligand is added at a concentration of 1 μM. Incubations are run in triplicate for 1 h at 37°C. |
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| References | [1]. Ruenitz PC, et al. Characterization of MCF 7 breast cancer cell growth inhibition by the antiestrogen nitromifene (CI 628) and selected metabolites. J Steroid Biochem. 1989 Sep;33(3):365-9. |
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Chemical & Physical Properties
| Density | 1.183g/cm3 |
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| Boiling Point | 576.7ºC at 760mmHg |
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| Molecular Formula | C27H28N2O4 |
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| Molecular Weight | 444.52200 |
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| Flash Point | 302.6ºC |
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| Exact Mass | 444.20500 |
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| PSA | 67.52000 |
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| LogP | 5.82420 |
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| Vapour Pressure | 2.66E-13mmHg at 25°C |
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| Index of Refraction | 1.605 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Nitromifeno [INN-Spanish] |
| CN-55,945 |
| 1-(4-<2-(1-pyrrolidinyl)ethoxy>phenyl)-1-(4-methoxyphenyl)-2-nitro-2-phenylethylene |
| 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-pyrrolidine |
| Nitromifenum [INN-Latin] |
| NITROMIFENE |
| Pyrrolidine,1-(2-(4-(1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl)phenoxy)ethyl) |
| nitromiphene |
| Nitromifeno |
