Introduction：Basic information about CAS 22246-18-0|3,4-Dihydro-7-hydroxy-2(1H)-quinolinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone |
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| CAS Number | 22246-18-0 | Molecular Weight | 163.173 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 403.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C9H9NO2 | Melting Point | 233-237 °C |
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| MSDS | ChineseUSA | Flash Point | 198.0±28.7 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 7-hydroxy-3,4-dihydro-1H-quinolin-2-one |
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| Synonym | More Synonyms |
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3,4-Dihydro-7-hydroxy-2(1H)-quinolinone BiologicalActivity
| Description | 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
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| Target | IC50: 183 μM (MAO-A)[1] |
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| In Vitro | 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. |
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| References | [1]. Meiring L, et al. Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5498-502. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 403.7±45.0 °C at 760 mmHg |
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| Melting Point | 233-237 °C |
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| Molecular Formula | C9H9NO2 |
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| Molecular Weight | 163.173 |
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| Flash Point | 198.0±28.7 °C |
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| Exact Mass | 163.063324 |
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| PSA | 49.33000 |
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| LogP | 0.99 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.604 |
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| InChIKey | LKLSFDWYIBUGNT-UHFFFAOYSA-N |
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| SMILES | O=C1CCc2ccc(O)cc2N1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H317 |
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| Precautionary Statements | P280 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
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| Hazard Codes | Xi: Irritant;Xn: Harmful; |
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| Risk Phrases | R22;R43 |
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| Safety Phrases | S36/37 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933499090 |
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Preparation
Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Synonyms
| 2,7-quinolinediol, 3,4-dihydro- |
| 3,4-Dihydro-7-hydroxycarbostyril |
| MFCD06410891 |
| 2(1H)-Quinolinone, 3,4-dihydro-7-hydroxy- |
| 7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline |
| 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone |
| 7-Hydroxy-3,4-dihydro-quinolin-2-one |
| 7-Hydroxy-3,4-dihydrochinolin-2(1H)-on |
| 7-hydroxy-3,4-dihydroquinolin-2(1H)-one |
| 7-hydroxy-3,4-dihydro-2-quinolinone |
| 7-Hydroxy-3,4-dihydro carbostyril |
| 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone |
| 7-hydroxy-3,4-dihydro-2(1H)quinolinone |
| Brexpiprazole Impurity 5 |
| Aripiprazole - Impurity A |
| 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone |
