Introduction：Basic information about CAS 76631-46-4|Detomidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Detomidine |
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| CAS Number | 76631-46-4 | Molecular Weight | 186.25300 |
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| Density | 1.077 g/cm3 | Boiling Point | 386.5ºC at 760 mmHg |
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| Molecular Formula | C12H14N2 | Melting Point | 160ºC |
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| MSDS | / | Flash Point | 200.6ºC |
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Names
| Name | 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole |
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| Synonym | More Synonyms |
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Detomidine BiologicalActivity
| Description | Detomidine produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorNatural Products >>AlkaloidResearch Areas >>Neurological Disease |
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| References | [1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7. |
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Chemical & Physical Properties
| Density | 1.077 g/cm3 |
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| Boiling Point | 386.5ºC at 760 mmHg |
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| Melting Point | 160ºC |
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| Molecular Formula | C12H14N2 |
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| Molecular Weight | 186.25300 |
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| Flash Point | 200.6ºC |
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| Exact Mass | 186.11600 |
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| PSA | 28.68000 |
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| LogP | 2.61730 |
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| Index of Refraction | 1.582 |
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| InChIKey | RHDJRPPFURBGLQ-UHFFFAOYSA-N |
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| SMILES | Cc1cccc(Cc2cnc[nH]2)c1C |
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Safety Information
Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| detomidine |
| unii-7n8k34p2xh |
