CAS 101020-89-7|Artemisitene

Introduction：Basic information about CAS 101020-89-7|Artemisitene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameArtemisitene
CAS Number101020-89-7Molecular Weight280.32
Density/Boiling Point/
Molecular FormulaC15H20O5Melting Point160-162°C (lit.)
MSDS/Flash Point/

Names

NameArtemisitene
SynonymMore Synonyms

Artemisitene BiologicalActivity

DescriptionArtemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>NF-κB >>Keap1-Nrf2Signaling Pathways >>Cell Cycle/DNA Damage >>Topoisomerase
In VitroArtemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4[2].
In VivoIn Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1].
References

[1]. Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30(7):2500-10.

[2]. Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37(37):5079-5087.

Chemical & Physical Properties

Melting Point160-162°C (lit.)
Molecular FormulaC15H20O5
Molecular Weight280.32
Exact Mass280.13100
PSA53.99000
LogP2.31500
Vapour Pressure3.52E-07mmHg at 25°C
InChIKeyIGEBZMMCKFUABB-IXVMMEEGSA-N
SMILESC=C1C(=O)OC2OC3(C)CCC4C(C)CCC1C24OO3
Storage condition2-8°C

Safety Information

Hazard CodesXi

Synonyms

artemisitene (methyl artemisinin)
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